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- W2079236516 abstract "Abstract Dogs were fed an arteriosclerosis-inducing diet which contained 16% hydrogenated coconut oil and 5% cholesterol, the same diet without cholesterol supplement, or meat-chow. The last diet group did not develop arteriosclerosis and was regarded as control. All animals showed severe arteriosclerotic lesions after 12–16 months on cholesterol supplement diet and after 4 months all showed ultrastructural changes in medial smooth muscle cells. Fatty acid patterns changed in all lipid fractions of intima-media of dogs on the supplemented diet, whereas in terms of fatty acid concentration, only triglyceride changed. All lipids showed their greatest increase in severely arteriosclerotic arteries of long-term dogs. Cholesteryl esters increased relatively more than other lipid fractions. Cholesteryl oleate increased most. Comparison of effects of short- and long-term feeding of cholesterol-supplemented diet indicates that some lipid changes in aortic intimamedia cannot be fully explained by simple filtration from plasma. Selective uptake, synthesis, degradation, or removal of lipids took place in situ. Changes in composition of lipids in the arterial wall, observed in this study, may alter arterial permeability, its enzymatic activity, or both. Greater deposition of plasma lipids probably then takes place at a later stage of arteriosclerotic involvement." @default.
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- W2079236516 date "1972-06-01" @default.
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- W2079236516 title "Aortic lipids at different stages of canine experimental arteriosclerosis" @default.
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- W2079236516 doi "https://doi.org/10.1016/0014-4800(72)90007-x" @default.
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