FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079237427> ?p ?o ?g. }

• W2079237427 endingPage "38" @default.
• W2079237427 startingPage "31" @default.
• W2079237427 abstract "Genetic polymorphisms that affect xenobiotic metabolism or cellular response to DNA damage can modulate individual sensitivity to genotoxins. Information on the effects of such polymorphisms on the level of chromosome damage may facilitate the identification of risk groups and increase the sensitivity of cytogenetic endpoints as biomarkers of genotoxic exposure and effect. Glutathione S-transferase M1 (GSTM1) is an important detoxification enzyme which, due to a homozygous gene deletion (null genotype), is lacking from about 50% of Caucasians. A higher level of DNA adducts and chromosome damage has been detected in lymphocytes of tobacco smokers and bus drivers who lack the GSTM1 gene. Other polymorphic glutathione S-transferases include GSTM3, GSTP1, and GSTT1. The GSTT1 null genotype (10-20% of Caucasians) has been associated with an increased baseline level of sister chromatid exchanges (SCEs) in lymphocytes. N-acetyltransferase 2 (NAT2), metabolizing xenobiotics with primary aromatic amine and hydrazine structures, is another important polymorphic phase II enzyme. Subjects having the NAT2 slow acetylator genotype appear to show an increased baseline frequency of lymphocyte CAs in the absence of identified environmental exposure. Besides human biomonitoring studies, genetic polymorphisms may be important in explaining individual variation in genotoxic response observed in genetic toxicology tests with human cells. Several studies have suggested that blood cultures from GSTT1 null and GSTM1 null individuals have increased in vitro sensitivity to various genotoxins. The best-known example is probably the diepoxybutane sensitivity of GSTT1 null donors. Recently discovered polymorphisms affecting DNA repair may be expected to be of special importance in modulating genotoxic effects; the first available studies have suggested that the exon 10 Arg399Gln polymorphism of XRCC1 gene (X-ray repair cross-complementing group 1) could affect individual genotoxic response. In conclusion, the genetic polymorphism of GSTM1 influences the frequency of chromosome damage in exposed humans, while that of GSTT1 and NAT2 affect the baseline level of such damage. Both GSTM1 and GSTT1 genotypes may shape the in vitro genotoxic response of human lymphocytes. The significance of DNA repair polymorphisms is presently unclear." @default.
• W2079237427 created "2016-06-24" @default.
• W2079237427 creator A5029987024 @default.
• W2079237427 date "2001-01-01" @default.
• W2079237427 modified "2023-10-09" @default.
• W2079237427 title "Genetic polymorphisms and chromosome damage" @default.
• W2079237427 cites W1511815964 @default.
• W2079237427 cites W1757108108 @default.
• W2079237427 cites W1969048085 @default.
• W2079237427 cites W1977200641 @default.
• W2079237427 cites W1983585864 @default.
• W2079237427 cites W1986952134 @default.
• W2079237427 cites W1993541953 @default.
• W2079237427 cites W1993676830 @default.
• W2079237427 cites W1994945319 @default.
• W2079237427 cites W1996709118 @default.
• W2079237427 cites W2001037328 @default.
• W2079237427 cites W2002240712 @default.
• W2079237427 cites W2006546698 @default.
• W2079237427 cites W2009876387 @default.
• W2079237427 cites W2012335460 @default.
• W2079237427 cites W2022166847 @default.
• W2079237427 cites W2022918939 @default.
• W2079237427 cites W2024527370 @default.
• W2079237427 cites W2028912672 @default.
• W2079237427 cites W2031019517 @default.
• W2079237427 cites W2048803885 @default.
• W2079237427 cites W2049394451 @default.
• W2079237427 cites W2057726005 @default.
• W2079237427 cites W2060056582 @default.
• W2079237427 cites W2068793970 @default.
• W2079237427 cites W2075602994 @default.
• W2079237427 cites W2076195346 @default.
• W2079237427 cites W2076589905 @default.
• W2079237427 cites W2086467936 @default.
• W2079237427 cites W2087588634 @default.
• W2079237427 cites W2091535349 @default.
• W2079237427 cites W2092034902 @default.
• W2079237427 cites W2094211790 @default.
• W2079237427 cites W2103324761 @default.
• W2079237427 cites W2107047644 @default.
• W2079237427 cites W2107737277 @default.
• W2079237427 cites W2113224103 @default.
• W2079237427 cites W2144790168 @default.
• W2079237427 cites W2155584141 @default.
• W2079237427 cites W2159558834 @default.
• W2079237427 cites W2167886614 @default.
• W2079237427 cites W2169426725 @default.
• W2079237427 cites W2169554211 @default.
• W2079237427 cites W2274170554 @default.
• W2079237427 cites W4360893946 @default.
• W2079237427 doi "https://doi.org/10.1078/1438-4639-00069" @default.
• W2079237427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11725342" @default.
• W2079237427 hasPublicationYear "2001" @default.
• W2079237427 type Work @default.
• W2079237427 sameAs 2079237427 @default.
• W2079237427 citedByCount "49" @default.
• W2079237427 countsByYear W20792374272012 @default.
• W2079237427 countsByYear W20792374272013 @default.
• W2079237427 countsByYear W20792374272014 @default.
• W2079237427 countsByYear W20792374272016 @default.
• W2079237427 countsByYear W20792374272018 @default.
• W2079237427 countsByYear W20792374272019 @default.
• W2079237427 countsByYear W20792374272021 @default.
• W2079237427 crossrefType "journal-article" @default.
• W2079237427 hasAuthorship W2079237427A5029987024 @default.
• W2079237427 hasConcept C104317684 @default.
• W2079237427 hasConcept C115448650 @default.
• W2079237427 hasConcept C134935766 @default.
• W2079237427 hasConcept C135763542 @default.
• W2079237427 hasConcept C143425029 @default.
• W2079237427 hasConcept C153911025 @default.
• W2079237427 hasConcept C181199279 @default.
• W2079237427 hasConcept C2776907368 @default.
• W2079237427 hasConcept C2780122483 @default.
• W2079237427 hasConcept C538909803 @default.
• W2079237427 hasConcept C54355233 @default.
• W2079237427 hasConcept C552990157 @default.
• W2079237427 hasConcept C55493867 @default.
• W2079237427 hasConcept C86803240 @default.
• W2079237427 hasConceptScore W2079237427C104317684 @default.
• W2079237427 hasConceptScore W2079237427C115448650 @default.
• W2079237427 hasConceptScore W2079237427C134935766 @default.
• W2079237427 hasConceptScore W2079237427C135763542 @default.
• W2079237427 hasConceptScore W2079237427C143425029 @default.
• W2079237427 hasConceptScore W2079237427C153911025 @default.
• W2079237427 hasConceptScore W2079237427C181199279 @default.
• W2079237427 hasConceptScore W2079237427C2776907368 @default.
• W2079237427 hasConceptScore W2079237427C2780122483 @default.
• W2079237427 hasConceptScore W2079237427C538909803 @default.
• W2079237427 hasConceptScore W2079237427C54355233 @default.
• W2079237427 hasConceptScore W2079237427C552990157 @default.
• W2079237427 hasConceptScore W2079237427C55493867 @default.
• W2079237427 hasConceptScore W2079237427C86803240 @default.
• W2079237427 hasIssue "1" @default.
• W2079237427 hasLocation W20792374271 @default.
• W2079237427 hasLocation W20792374272 @default.
• W2079237427 hasOpenAccess W2079237427 @default.

• next