FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079237568> ?p ?o ?g. }

• W2079237568 abstract "Specific, transforming point mutations of ras and alterations in ras expression have been associated with many neoplastic processes, and their presence may be pivotal in neoplastic transformation. Our objective were to evaluate the molecular and genetic alterations of Ki-ras in preneoplastic foci and neoplasms in the lungs of rats that inhaled 239PuO2 aerosols. Histologically classified pulmonary lesions were evaluated by in vitro nucleic acid amplification, oligonucleotide hybridization, and direct nucleic acid sequencing for activating Ki-ras point mutations. We evaluated ras expression in similar lesions using immunohistochemistry and in situ hybridization. Specific Ki-ras point mutations were present in 46% of the radiation-induced malignant neoplasms. Spontaneous pulmonary neoplasms, which are rare in rats, had similar activating mutations and frequencies (40%). We found similar mutation frequencies in radiation-induced adenomas and foci of alveolar epithelial hyperplasia. No mutations were identified in normal lung tissue. Ras expression in hyperplastic lesions and neoplasms was similar to that observed in normal pulmonary epithelia. These findings suggest that Ki-ras activation, not alterations in expression, is an early lesion associated with many radiation-induced, proliferative pulmonary lesions and that this molecular alteration may be an important component of both radiation-induced and spontaneous pulmonary carcinogenesis in the rat." @default.
• W2079237568 created "2016-06-24" @default.
• W2079237568 creator A5024318408 @default.
• W2079237568 creator A5041187574 @default.
• W2079237568 creator A5078855411 @default.
• W2079237568 creator A5086358405 @default.
• W2079237568 date "1991-01-01" @default.
• W2079237568 modified "2023-09-23" @default.
• W2079237568 title "The molecular progression of plutonium-239–induced rat lung carcinogenesis: Ki-ras expression and activation" @default.
• W2079237568 cites W1746552425 @default.
• W2079237568 cites W1812742151 @default.
• W2079237568 cites W1973677994 @default.
• W2079237568 cites W1973800266 @default.
• W2079237568 cites W1980724110 @default.
• W2079237568 cites W1985651419 @default.
• W2079237568 cites W1991131571 @default.
• W2079237568 cites W2001070612 @default.
• W2079237568 cites W2001258296 @default.
• W2079237568 cites W2005547612 @default.
• W2079237568 cites W2005742641 @default.
• W2079237568 cites W2014435471 @default.
• W2079237568 cites W2048649566 @default.
• W2079237568 cites W2050760539 @default.
• W2079237568 cites W2052815245 @default.
• W2079237568 cites W2063769545 @default.
• W2079237568 cites W2070132447 @default.
• W2079237568 cites W2075300416 @default.
• W2079237568 cites W2077501534 @default.
• W2079237568 cites W2080484121 @default.
• W2079237568 cites W2082027741 @default.
• W2079237568 cites W2083329677 @default.
• W2079237568 cites W2084695608 @default.
• W2079237568 cites W2087441022 @default.
• W2079237568 cites W2087884848 @default.
• W2079237568 cites W2091723114 @default.
• W2079237568 cites W2096428903 @default.
• W2079237568 cites W2098260332 @default.
• W2079237568 cites W2126284695 @default.
• W2079237568 cites W2142454421 @default.
• W2079237568 cites W2320138981 @default.
• W2079237568 cites W2337358073 @default.
• W2079237568 cites W4232777855 @default.
• W2079237568 cites W65122394 @default.
• W2079237568 cites W133164353 @default.
• W2079237568 cites W2092826925 @default.
• W2079237568 doi "https://doi.org/10.1002/mc.2940040108" @default.
• W2079237568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2009134" @default.
• W2079237568 hasPublicationYear "1991" @default.
• W2079237568 type Work @default.
• W2079237568 sameAs 2079237568 @default.
• W2079237568 citedByCount "32" @default.
• W2079237568 countsByYear W20792375682012 @default.
• W2079237568 countsByYear W20792375682015 @default.
• W2079237568 countsByYear W20792375682016 @default.
• W2079237568 crossrefType "journal-article" @default.
• W2079237568 hasAuthorship W2079237568A5024318408 @default.
• W2079237568 hasAuthorship W2079237568A5041187574 @default.
• W2079237568 hasAuthorship W2079237568A5078855411 @default.
• W2079237568 hasAuthorship W2079237568A5086358405 @default.
• W2079237568 hasConcept C104317684 @default.
• W2079237568 hasConcept C126322002 @default.
• W2079237568 hasConcept C134018914 @default.
• W2079237568 hasConcept C142724271 @default.
• W2079237568 hasConcept C150194340 @default.
• W2079237568 hasConcept C153911025 @default.
• W2079237568 hasConcept C176944494 @default.
• W2079237568 hasConcept C203014093 @default.
• W2079237568 hasConcept C204232928 @default.
• W2079237568 hasConcept C2776256026 @default.
• W2079237568 hasConcept C2777562237 @default.
• W2079237568 hasConcept C2777714996 @default.
• W2079237568 hasConcept C2781156865 @default.
• W2079237568 hasConcept C501734568 @default.
• W2079237568 hasConcept C502942594 @default.
• W2079237568 hasConcept C54355233 @default.
• W2079237568 hasConcept C555283112 @default.
• W2079237568 hasConcept C71924100 @default.
• W2079237568 hasConcept C81439078 @default.
• W2079237568 hasConcept C86803240 @default.
• W2079237568 hasConceptScore W2079237568C104317684 @default.
• W2079237568 hasConceptScore W2079237568C126322002 @default.
• W2079237568 hasConceptScore W2079237568C134018914 @default.
• W2079237568 hasConceptScore W2079237568C142724271 @default.
• W2079237568 hasConceptScore W2079237568C150194340 @default.
• W2079237568 hasConceptScore W2079237568C153911025 @default.
• W2079237568 hasConceptScore W2079237568C176944494 @default.
• W2079237568 hasConceptScore W2079237568C203014093 @default.
• W2079237568 hasConceptScore W2079237568C204232928 @default.
• W2079237568 hasConceptScore W2079237568C2776256026 @default.
• W2079237568 hasConceptScore W2079237568C2777562237 @default.
• W2079237568 hasConceptScore W2079237568C2777714996 @default.
• W2079237568 hasConceptScore W2079237568C2781156865 @default.
• W2079237568 hasConceptScore W2079237568C501734568 @default.
• W2079237568 hasConceptScore W2079237568C502942594 @default.
• W2079237568 hasConceptScore W2079237568C54355233 @default.
• W2079237568 hasConceptScore W2079237568C555283112 @default.
• W2079237568 hasConceptScore W2079237568C71924100 @default.
• W2079237568 hasConceptScore W2079237568C81439078 @default.
• W2079237568 hasConceptScore W2079237568C86803240 @default.
• W2079237568 hasLocation W20792375681 @default.

• next