Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079237812> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2079237812 abstract "The paper describes the dissociation parameters of the complexes between [3H]-digitoxin and Na,K-ATPase (Na+ + K+-activated, Mg2+-dependent ATP phosphohydrolase, E.C. 3.6.1.3) from pig cardiac muscle and brain cortex formed and dissociated in the presence of different combinations and concentrations of the enzyme effectors ATP, Mg2+, Na+ and K+. Systematic variation of effector-ligation of Na,K-ATPase allowed production of glycoside complexes with two enzyme conformers only, which showed either rapid or slow dissociation kinetics. Appropriate changes of enzyme ligation allowed the interconversion of the two conformer types. Biphasic, rapid and slow glycoside release was not bound with the presence of two Na,K-ATPase isozymes, but caused by the enzyme ligation-determined coexistence of the two conformers of Na,K-ATPase. The rate constants for the rapid and slow glycoside release were within the complexes of each dissociation type much alike indicating uniform isomerization kinetics of the two conformers even when differently liganded. Taken together, the observations indicated the effector-controlled isomerizations of two conformers of Na,K-ATPase possessing different geometries of the glycoside binding domain. Present findings and relevant literature data were integrated in a circular, consecutive and simultaneous model for induced conformation changes that accounted for the regulation of the interaction of cardiac glycosides and Na,K-ATPase through an effector-controlled equilibrium between two limit enzyme conformers." @default.
- W2079237812 created "2016-06-24" @default.
- W2079237812 creator A5003024714 @default.
- W2079237812 creator A5020983655 @default.
- W2079237812 creator A5039532182 @default.
- W2079237812 date "1984-07-01" @default.
- W2079237812 modified "2023-09-25" @default.
- W2079237812 title "Interaction of cardiac glycosides and Na,K-ATPase is regulated by effector-controlled equilibrium between two limit enzyme conformers" @default.
- W2079237812 cites W1508147765 @default.
- W2079237812 cites W1573534810 @default.
- W2079237812 cites W1590045255 @default.
- W2079237812 cites W1758970340 @default.
- W2079237812 cites W1775749144 @default.
- W2079237812 cites W1916632538 @default.
- W2079237812 cites W1960643350 @default.
- W2079237812 cites W1979845674 @default.
- W2079237812 cites W1983083820 @default.
- W2079237812 cites W1989872796 @default.
- W2079237812 cites W1993989491 @default.
- W2079237812 cites W1998209711 @default.
- W2079237812 cites W1999030934 @default.
- W2079237812 cites W2007684377 @default.
- W2079237812 cites W2019398276 @default.
- W2079237812 cites W2027806163 @default.
- W2079237812 cites W2028879876 @default.
- W2079237812 cites W2034880050 @default.
- W2079237812 cites W2035257912 @default.
- W2079237812 cites W2043112035 @default.
- W2079237812 cites W2045098309 @default.
- W2079237812 cites W206994910 @default.
- W2079237812 cites W2085722214 @default.
- W2079237812 cites W2111717586 @default.
- W2079237812 cites W2118002848 @default.
- W2079237812 cites W2121256167 @default.
- W2079237812 cites W2129527881 @default.
- W2079237812 cites W2151584993 @default.
- W2079237812 cites W2201892421 @default.
- W2079237812 doi "https://doi.org/10.1016/0006-2952(84)90578-1" @default.
- W2079237812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6331458" @default.
- W2079237812 hasPublicationYear "1984" @default.
- W2079237812 type Work @default.
- W2079237812 sameAs 2079237812 @default.
- W2079237812 citedByCount "16" @default.
- W2079237812 crossrefType "journal-article" @default.
- W2079237812 hasAuthorship W2079237812A5003024714 @default.
- W2079237812 hasAuthorship W2079237812A5020983655 @default.
- W2079237812 hasAuthorship W2079237812A5039532182 @default.
- W2079237812 hasConcept C102931765 @default.
- W2079237812 hasConcept C121332964 @default.
- W2079237812 hasConcept C148898269 @default.
- W2079237812 hasConcept C178790620 @default.
- W2079237812 hasConcept C181199279 @default.
- W2079237812 hasConcept C185592680 @default.
- W2079237812 hasConcept C18705241 @default.
- W2079237812 hasConcept C194671627 @default.
- W2079237812 hasConcept C23265538 @default.
- W2079237812 hasConcept C2779133857 @default.
- W2079237812 hasConcept C2780557390 @default.
- W2079237812 hasConcept C32909587 @default.
- W2079237812 hasConcept C537181965 @default.
- W2079237812 hasConcept C55493867 @default.
- W2079237812 hasConcept C62520636 @default.
- W2079237812 hasConcept C71240020 @default.
- W2079237812 hasConceptScore W2079237812C102931765 @default.
- W2079237812 hasConceptScore W2079237812C121332964 @default.
- W2079237812 hasConceptScore W2079237812C148898269 @default.
- W2079237812 hasConceptScore W2079237812C178790620 @default.
- W2079237812 hasConceptScore W2079237812C181199279 @default.
- W2079237812 hasConceptScore W2079237812C185592680 @default.
- W2079237812 hasConceptScore W2079237812C18705241 @default.
- W2079237812 hasConceptScore W2079237812C194671627 @default.
- W2079237812 hasConceptScore W2079237812C23265538 @default.
- W2079237812 hasConceptScore W2079237812C2779133857 @default.
- W2079237812 hasConceptScore W2079237812C2780557390 @default.
- W2079237812 hasConceptScore W2079237812C32909587 @default.
- W2079237812 hasConceptScore W2079237812C537181965 @default.
- W2079237812 hasConceptScore W2079237812C55493867 @default.
- W2079237812 hasConceptScore W2079237812C62520636 @default.
- W2079237812 hasConceptScore W2079237812C71240020 @default.
- W2079237812 hasLocation W20792378121 @default.
- W2079237812 hasLocation W20792378122 @default.
- W2079237812 hasOpenAccess W2079237812 @default.
- W2079237812 hasPrimaryLocation W20792378121 @default.
- W2079237812 hasRelatedWork W1972698314 @default.
- W2079237812 hasRelatedWork W1979064489 @default.
- W2079237812 hasRelatedWork W1984088856 @default.
- W2079237812 hasRelatedWork W2006117067 @default.
- W2079237812 hasRelatedWork W2031537740 @default.
- W2079237812 hasRelatedWork W2057496258 @default.
- W2079237812 hasRelatedWork W2082645421 @default.
- W2079237812 hasRelatedWork W2091165889 @default.
- W2079237812 hasRelatedWork W2197278359 @default.
- W2079237812 hasRelatedWork W2294282582 @default.
- W2079237812 isParatext "false" @default.
- W2079237812 isRetracted "false" @default.
- W2079237812 magId "2079237812" @default.
- W2079237812 workType "article" @default.