Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079239134> ?p ?o ?g. }
- W2079239134 endingPage "288" @default.
- W2079239134 startingPage "283" @default.
- W2079239134 abstract "Soluble cytokine receptors appear to modify ligand concentrations by stabilizing ligands or by specifically inhibiting interactions of ligands with their membrane‐bound receptors. Here we describe a new function of the soluble interleukin‐1 receptor type I (IL‐1sR I). This receptor induced a transient rise of intracellular free calcium concentration in human dermal fibroblasts in a dose‐dependent fashion. Mobilization of calcium by IL‐1sR I was abolished in the presence of an equimolar concentration of IL‐1 receptor antagonist (IL‐1ra). Neutralizing antibodies against IL‐1β also abolished calcium mobilization stimulated with IL‐1sR I indicating that IL‐1β is involved. IL‐1sR I bound with high affinity ( K d 1–2 nM) to the fibroblasts. In addition, IL‐1sR I enhanced expression of IL‐6 and IL‐8 mRNA. The observation that IL‐1sR I can act as a ligand and agonist for membrane IL‐1 extends the concept of the ligand‐receptor functions of both IL‐1 and IL‐1sR I and adds a new dimension to the cytokine network." @default.
- W2079239134 created "2016-06-24" @default.
- W2079239134 creator A5002581370 @default.
- W2079239134 creator A5045971138 @default.
- W2079239134 creator A5051730822 @default.
- W2079239134 creator A5052120678 @default.
- W2079239134 creator A5060295342 @default.
- W2079239134 creator A5069673746 @default.
- W2079239134 creator A5072194821 @default.
- W2079239134 date "1998-09-04" @default.
- W2079239134 modified "2023-09-27" @default.
- W2079239134 title "Soluble IL-1 receptor type I binds to human dermal fibroblasts and induces calcium flux" @default.
- W2079239134 cites W136692196 @default.
- W2079239134 cites W1483907253 @default.
- W2079239134 cites W1512443712 @default.
- W2079239134 cites W1514081838 @default.
- W2079239134 cites W1515994079 @default.
- W2079239134 cites W1543321352 @default.
- W2079239134 cites W1574290496 @default.
- W2079239134 cites W1581990512 @default.
- W2079239134 cites W1832347676 @default.
- W2079239134 cites W1910189841 @default.
- W2079239134 cites W1915518296 @default.
- W2079239134 cites W1965343363 @default.
- W2079239134 cites W1970931608 @default.
- W2079239134 cites W1977443234 @default.
- W2079239134 cites W1980776688 @default.
- W2079239134 cites W2021045520 @default.
- W2079239134 cites W2028553251 @default.
- W2079239134 cites W2031670584 @default.
- W2079239134 cites W2050218326 @default.
- W2079239134 cites W2063535351 @default.
- W2079239134 cites W2076918198 @default.
- W2079239134 cites W2078136106 @default.
- W2079239134 cites W2085451664 @default.
- W2079239134 cites W2091996917 @default.
- W2079239134 cites W2139433070 @default.
- W2079239134 cites W2159128841 @default.
- W2079239134 cites W2161033554 @default.
- W2079239134 cites W2229564346 @default.
- W2079239134 cites W291298043 @default.
- W2079239134 cites W38793834 @default.
- W2079239134 doi "https://doi.org/10.1016/s0014-5793(98)00995-8" @default.
- W2079239134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9742939" @default.
- W2079239134 hasPublicationYear "1998" @default.
- W2079239134 type Work @default.
- W2079239134 sameAs 2079239134 @default.
- W2079239134 citedByCount "11" @default.
- W2079239134 countsByYear W20792391342013 @default.
- W2079239134 countsByYear W20792391342018 @default.
- W2079239134 crossrefType "journal-article" @default.
- W2079239134 hasAuthorship W2079239134A5002581370 @default.
- W2079239134 hasAuthorship W2079239134A5045971138 @default.
- W2079239134 hasAuthorship W2079239134A5051730822 @default.
- W2079239134 hasAuthorship W2079239134A5052120678 @default.
- W2079239134 hasAuthorship W2079239134A5060295342 @default.
- W2079239134 hasAuthorship W2079239134A5069673746 @default.
- W2079239134 hasAuthorship W2079239134A5072194821 @default.
- W2079239134 hasBestOaLocation W20792391341 @default.
- W2079239134 hasConcept C153911025 @default.
- W2079239134 hasConcept C170493617 @default.
- W2079239134 hasConcept C178790620 @default.
- W2079239134 hasConcept C181080969 @default.
- W2079239134 hasConcept C185592680 @default.
- W2079239134 hasConcept C187316574 @default.
- W2079239134 hasConcept C203014093 @default.
- W2079239134 hasConcept C2778690821 @default.
- W2079239134 hasConcept C2778938600 @default.
- W2079239134 hasConcept C519063684 @default.
- W2079239134 hasConcept C55493867 @default.
- W2079239134 hasConcept C86803240 @default.
- W2079239134 hasConceptScore W2079239134C153911025 @default.
- W2079239134 hasConceptScore W2079239134C170493617 @default.
- W2079239134 hasConceptScore W2079239134C178790620 @default.
- W2079239134 hasConceptScore W2079239134C181080969 @default.
- W2079239134 hasConceptScore W2079239134C185592680 @default.
- W2079239134 hasConceptScore W2079239134C187316574 @default.
- W2079239134 hasConceptScore W2079239134C203014093 @default.
- W2079239134 hasConceptScore W2079239134C2778690821 @default.
- W2079239134 hasConceptScore W2079239134C2778938600 @default.
- W2079239134 hasConceptScore W2079239134C519063684 @default.
- W2079239134 hasConceptScore W2079239134C55493867 @default.
- W2079239134 hasConceptScore W2079239134C86803240 @default.
- W2079239134 hasIssue "3" @default.
- W2079239134 hasLocation W20792391341 @default.
- W2079239134 hasLocation W20792391342 @default.
- W2079239134 hasOpenAccess W2079239134 @default.
- W2079239134 hasPrimaryLocation W20792391341 @default.
- W2079239134 hasRelatedWork W1979013132 @default.
- W2079239134 hasRelatedWork W1988001779 @default.
- W2079239134 hasRelatedWork W2002569533 @default.
- W2079239134 hasRelatedWork W2042405111 @default.
- W2079239134 hasRelatedWork W2141926683 @default.
- W2079239134 hasRelatedWork W2406295010 @default.
- W2079239134 hasRelatedWork W2411134315 @default.
- W2079239134 hasRelatedWork W2420935970 @default.
- W2079239134 hasRelatedWork W2888617702 @default.
- W2079239134 hasRelatedWork W4286856416 @default.