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- W2079240711 abstract "Abstract 1. 1. Sixteen pesticides, one carcinogen (3-methylcholanthrene), one cotton defoliant, two drugs (phenobarbital and chloral hydrate) and two insecticide synergists (piperonyl butoxide and sesamex) were administered to adult male mice by different routes in order to evaluate the inductive effects of pesticides on hepatic drug metabolizing enzymes. 2. 2. Of the experimental insecticides screened, TH-6042 (a substituted pyrazoline) showed the highest level of induction of cytochrome P-450 (>3-fold) and also significant increases in O-demethylation of p -nitroanisole and N -demethylation of aminopyrine. 3. 3. Maximum induction was generally achieved when compounds were administered orally for each of 3 days." @default.
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- W2079240711 date "1980-01-01" @default.
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- W2079240711 title "Pesticides as inducers of hepatic drug-metabolizing enzymes—I. Mixed function oxidase activity" @default.
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- W2079240711 doi "https://doi.org/10.1016/0306-3623(80)90028-2" @default.
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