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• W2079242583 abstract "Summary Objective To analyse the performance of the desmopressin ( DDAVP ) test in the diagnosis of Cushing's disease ( CD ). Methods This was a prospective cohort study of 124 patients with suspected hypercortisolism who were recruited from an outpatient endocrinology clinic and investigated for Cushing's syndrome ( CS ). The ACTH and cortisol responses to the DDAVP test were assessed to determine patient diagnosis and test the procedure's diagnostic accuracy. Results A total of 68 patients had CD , while 56 had suspected CS . According to ROC analysis, an ACTH peak of 71·8 pg/ml (15·8 pmol/l) following DDAVP administration was able to diagnose CD with a specificity of 94·6% and a sensitivity of 90·8%, a negative predictive value ( NPV ) of 89·9% and a positive predictive value ( PPV ) of 95·3%. An absolute ACTH increment ≥37 pg/ml (8·1 pmol/l) over baseline had a sensitivity of 88·0%, specificity of 96·4%, NPV of 87·0% and PPV of 95·3% in diagnosing CD . Only 2 of 56 cases without CD had an absolute ACTH increment ≥37 pg/ml (8·1 pmol/l) over baseline. The DDAVP test was superior to other clinical instruments in diagnosing CS . Conclusions The DDAVP test could be a useful additional tool to diagnose CD in patients with suspected CS ." @default.
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• W2079242583 date "2014-12-22" @default.
• W2079242583 modified "2023-10-11" @default.
• W2079242583 title "Evaluation of the <scp>DDAVP</scp> test in the diagnosis of Cushing's Disease" @default.
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• W2079242583 doi "https://doi.org/10.1111/cen.12661" @default.
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