FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079246504> ?p ?o ?g. }

• W2079246504 endingPage "355" @default.
• W2079246504 startingPage "346" @default.
• W2079246504 abstract "Impairment of mitochondrial function might contribute to oxidative stress associated with neurodegeneration in amyotrophic lateral sclerosis (ALS). Glutamate levels in tissues of ALS patients are sometimes altered. In neurons, mitochondrial metabolism of exogenous glutamine is mainly responsible for the net synthesis of glutamate, which is a neurotransmitter, but it is also necessary for the synthesis of glutathione, the main endogenous antioxidant. We investigated glutathione synthesis and glutamine/glutamate metabolism in a motor neuronal model of familial ALS. In standard culture conditions (with glutamine) or restricting glutamine or cystine, the level of glutathione was always lower in the cell line expressing the mutant (G93A) human Cu, Zn superoxide dismutase (G93ASOD1) than in the line expressing wild-type SOD1. With glutamine the difference in glutathione was associated with a lower glutamate and impairment of the glutamine/glutamate metabolism as evidenced by lower glutaminase and cytosolic malate dehydrogenase activity. d-β-hydroxybutyrate, as an alternative to glutamine as energy substrate in addition to glucose, reversed the decreases of cytosolic malate dehydrogenase activity and glutamate and glutathione. However, in the G93ASOD1 cell line, in all culture conditions the expression of pyruvate dehydrogenase kinase l protein, which down-regulates pyruvate dehydrogenase activity, was induced, together with an increase in lactate release in the medium. These findings suggest that the glutathione decrease associated with mutant SOD1 expression is due to mitochondrial dysfunction caused by the reduction of the flow of glucose-derived pyruvate through the TCA cycle; it implies altered glutamate metabolism and depends on the different mitochondrial energy substrates." @default.
• W2079246504 created "2016-06-24" @default.
• W2079246504 creator A5006518887 @default.
• W2079246504 creator A5016522209 @default.
• W2079246504 creator A5023802367 @default.
• W2079246504 creator A5036151148 @default.
• W2079246504 creator A5055763566 @default.
• W2079246504 creator A5083513390 @default.
• W2079246504 date "2011-08-01" @default.
• W2079246504 modified "2023-09-23" @default.
• W2079246504 title "Glutamate and glutathione interplay in a motor neuronal model of amyotrophic lateral sclerosis reveals altered energy metabolism" @default.
• W2079246504 cites W1485144031 @default.
• W2079246504 cites W1742516846 @default.
• W2079246504 cites W1902785172 @default.
• W2079246504 cites W1963646537 @default.
• W2079246504 cites W1969275215 @default.
• W2079246504 cites W1983842067 @default.
• W2079246504 cites W2006177769 @default.
• W2079246504 cites W2007298590 @default.
• W2079246504 cites W2011007124 @default.
• W2079246504 cites W2027671847 @default.
• W2079246504 cites W2032022303 @default.
• W2079246504 cites W2033715814 @default.
• W2079246504 cites W2033958147 @default.
• W2079246504 cites W2040678584 @default.
• W2079246504 cites W2043225644 @default.
• W2079246504 cites W2043304626 @default.
• W2079246504 cites W2046205615 @default.
• W2079246504 cites W2049225057 @default.
• W2079246504 cites W2051176464 @default.
• W2079246504 cites W2051886358 @default.
• W2079246504 cites W2052332287 @default.
• W2079246504 cites W2054698000 @default.
• W2079246504 cites W2056714779 @default.
• W2079246504 cites W2063176912 @default.
• W2079246504 cites W2067007754 @default.
• W2079246504 cites W2068997428 @default.
• W2079246504 cites W2071927278 @default.
• W2079246504 cites W2074839068 @default.
• W2079246504 cites W2075650099 @default.
• W2079246504 cites W2077954885 @default.
• W2079246504 cites W2079224025 @default.
• W2079246504 cites W2081362575 @default.
• W2079246504 cites W2084221805 @default.
• W2079246504 cites W2092595502 @default.
• W2079246504 cites W2098685543 @default.
• W2079246504 cites W2102247427 @default.
• W2079246504 cites W2115099018 @default.
• W2079246504 cites W2116035317 @default.
• W2079246504 cites W2116113384 @default.
• W2079246504 cites W2125034085 @default.
• W2079246504 cites W2128845732 @default.
• W2079246504 cites W2131678573 @default.
• W2079246504 cites W2133836078 @default.
• W2079246504 cites W2135118981 @default.
• W2079246504 cites W2143165981 @default.
• W2079246504 cites W2143313829 @default.
• W2079246504 cites W2147849026 @default.
• W2079246504 cites W2158261823 @default.
• W2079246504 cites W2165492152 @default.
• W2079246504 cites W4242174061 @default.
• W2079246504 cites W1978444766 @default.
• W2079246504 doi "https://doi.org/10.1016/j.nbd.2011.04.003" @default.
• W2079246504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21530659" @default.
• W2079246504 hasPublicationYear "2011" @default.
• W2079246504 type Work @default.
• W2079246504 sameAs 2079246504 @default.
• W2079246504 citedByCount "52" @default.
• W2079246504 countsByYear W20792465042012 @default.
• W2079246504 countsByYear W20792465042013 @default.
• W2079246504 countsByYear W20792465042014 @default.
• W2079246504 countsByYear W20792465042015 @default.
• W2079246504 countsByYear W20792465042016 @default.
• W2079246504 countsByYear W20792465042017 @default.
• W2079246504 countsByYear W20792465042018 @default.
• W2079246504 countsByYear W20792465042019 @default.
• W2079246504 countsByYear W20792465042020 @default.
• W2079246504 countsByYear W20792465042021 @default.
• W2079246504 countsByYear W20792465042022 @default.
• W2079246504 countsByYear W20792465042023 @default.
• W2079246504 crossrefType "journal-article" @default.
• W2079246504 hasAuthorship W2079246504A5006518887 @default.
• W2079246504 hasAuthorship W2079246504A5016522209 @default.
• W2079246504 hasAuthorship W2079246504A5023802367 @default.
• W2079246504 hasAuthorship W2079246504A5036151148 @default.
• W2079246504 hasAuthorship W2079246504A5055763566 @default.
• W2079246504 hasAuthorship W2079246504A5083513390 @default.
• W2079246504 hasConcept C109549099 @default.
• W2079246504 hasConcept C165135838 @default.
• W2079246504 hasConcept C170493617 @default.
• W2079246504 hasConcept C181199279 @default.
• W2079246504 hasConcept C2775838275 @default.
• W2079246504 hasConcept C2776151105 @default.
• W2079246504 hasConcept C2777202666 @default.
• W2079246504 hasConcept C2777615887 @default.
• W2079246504 hasConcept C2779349466 @default.
• W2079246504 hasConcept C515207424 @default.
• W2079246504 hasConcept C538909803 @default.

• next