Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079247922> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2079247922 endingPage "542" @default.
- W2079247922 startingPage "531" @default.
- W2079247922 abstract "Transforming growth factor (TGF)-β is secreted as an inactive complex, which frequently contains a large molecular weight binding protein designated latent TGF-β-binding protein (LTBP). Recently, the LTBPs have been shown to be a gene family that contains three known members and exhibits a multidomain structure containing cysteine-rich motifs that are also found in the fibrillin gene family. The present work seeks to characterize the gene encoding LTBP-2 and to compare its features to that of the other LTBPs and to the fibrillins. Human fibroblast libraries were used to isolate cDNA encoding LTBP-2 which was then used to identify LTBP-2 transcripts and to isolate the corresponding LTBP-2 gene. The cloned cDNA encodes a 195 kDa protein containing 20 epidermal growth factor (EGF)-like repeats, three repeats containing eight cysteins, and one segment that appears to be a hybrid of the two. Single exons encode EGF repeats while the eight-cysteine repeats are encoded in two exons. Northern analysis identified two transcripts of 7.5 and 9.0 kb, with the presently analyzed cDNA probably corresponding to the 7.5 transcript. Phylogenetic sequence comparisons demonstrated that LTBP-3 is more similar to LTBP-1 than LTBP-2, while LTBP-2 shows the most similarity to the fibrillins. These analyses suggest that LTBP-1 diverged from LTBP-3, and that LTBP-2 diverged from LTBP-1. Within the fibrillin family, fibrillin-1 is nearest to the LTBPs. While the domain structure of LTBP-2 is similar to that of the other LTBPs, LTBP-2 possesses unique regions that make it the largest member of the LTBP family. LTBP-2 may have dual functions as a member of the TGF-β latent complex and as a structural component of microfibrils." @default.
- W2079247922 created "2016-06-24" @default.
- W2079247922 creator A5001196534 @default.
- W2079247922 creator A5007295816 @default.
- W2079247922 creator A5022736570 @default.
- W2079247922 creator A5040041847 @default.
- W2079247922 creator A5059083549 @default.
- W2079247922 creator A5068418680 @default.
- W2079247922 creator A5073597690 @default.
- W2079247922 creator A5078532803 @default.
- W2079247922 creator A5088529813 @default.
- W2079247922 date "1996-05-01" @default.
- W2079247922 modified "2023-10-14" @default.
- W2079247922 title "Analysis of the human gene encoding latent transforming growth factor-β-binding protein-2" @default.
- W2079247922 cites W1600868878 @default.
- W2079247922 cites W163466579 @default.
- W2079247922 cites W1801477330 @default.
- W2079247922 cites W1972934993 @default.
- W2079247922 cites W1984889153 @default.
- W2079247922 cites W2010814775 @default.
- W2079247922 cites W2046902885 @default.
- W2079247922 cites W2084748297 @default.
- W2079247922 cites W2086833378 @default.
- W2079247922 cites W2091239909 @default.
- W2079247922 cites W2106213046 @default.
- W2079247922 cites W2106882534 @default.
- W2079247922 cites W2155437551 @default.
- W2079247922 cites W2166224134 @default.
- W2079247922 cites W4235224941 @default.
- W2079247922 cites W4254275792 @default.
- W2079247922 cites W4254469900 @default.
- W2079247922 doi "https://doi.org/10.1016/1357-2725(95)00167-0" @default.
- W2079247922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8697098" @default.
- W2079247922 hasPublicationYear "1996" @default.
- W2079247922 type Work @default.
- W2079247922 sameAs 2079247922 @default.
- W2079247922 citedByCount "20" @default.
- W2079247922 countsByYear W20792479222015 @default.
- W2079247922 countsByYear W20792479222021 @default.
- W2079247922 crossrefType "journal-article" @default.
- W2079247922 hasAuthorship W2079247922A5001196534 @default.
- W2079247922 hasAuthorship W2079247922A5007295816 @default.
- W2079247922 hasAuthorship W2079247922A5022736570 @default.
- W2079247922 hasAuthorship W2079247922A5040041847 @default.
- W2079247922 hasAuthorship W2079247922A5059083549 @default.
- W2079247922 hasAuthorship W2079247922A5068418680 @default.
- W2079247922 hasAuthorship W2079247922A5073597690 @default.
- W2079247922 hasAuthorship W2079247922A5078532803 @default.
- W2079247922 hasAuthorship W2079247922A5088529813 @default.
- W2079247922 hasConcept C104317684 @default.
- W2079247922 hasConcept C146759223 @default.
- W2079247922 hasConcept C150194340 @default.
- W2079247922 hasConcept C153911025 @default.
- W2079247922 hasConcept C187882448 @default.
- W2079247922 hasConcept C36823959 @default.
- W2079247922 hasConcept C54355233 @default.
- W2079247922 hasConcept C5911399 @default.
- W2079247922 hasConcept C76334062 @default.
- W2079247922 hasConcept C86803240 @default.
- W2079247922 hasConceptScore W2079247922C104317684 @default.
- W2079247922 hasConceptScore W2079247922C146759223 @default.
- W2079247922 hasConceptScore W2079247922C150194340 @default.
- W2079247922 hasConceptScore W2079247922C153911025 @default.
- W2079247922 hasConceptScore W2079247922C187882448 @default.
- W2079247922 hasConceptScore W2079247922C36823959 @default.
- W2079247922 hasConceptScore W2079247922C54355233 @default.
- W2079247922 hasConceptScore W2079247922C5911399 @default.
- W2079247922 hasConceptScore W2079247922C76334062 @default.
- W2079247922 hasConceptScore W2079247922C86803240 @default.
- W2079247922 hasIssue "5" @default.
- W2079247922 hasLocation W20792479221 @default.
- W2079247922 hasLocation W20792479222 @default.
- W2079247922 hasOpenAccess W2079247922 @default.
- W2079247922 hasPrimaryLocation W20792479221 @default.
- W2079247922 hasRelatedWork W1980617967 @default.
- W2079247922 hasRelatedWork W2005125972 @default.
- W2079247922 hasRelatedWork W2007559212 @default.
- W2079247922 hasRelatedWork W2009810944 @default.
- W2079247922 hasRelatedWork W2009966535 @default.
- W2079247922 hasRelatedWork W2013108791 @default.
- W2079247922 hasRelatedWork W2025338956 @default.
- W2079247922 hasRelatedWork W2088017464 @default.
- W2079247922 hasRelatedWork W2168467210 @default.
- W2079247922 hasRelatedWork W2375466314 @default.
- W2079247922 hasVolume "28" @default.
- W2079247922 isParatext "false" @default.
- W2079247922 isRetracted "false" @default.
- W2079247922 magId "2079247922" @default.
- W2079247922 workType "article" @default.