FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079249283> ?p ?o ?g. }

• W2079249283 endingPage "e18867" @default.
• W2079249283 startingPage "e18867" @default.
• W2079249283 abstract "A large number of gene expression profiling (GEP) studies on prognosis of colorectal cancer (CRC) has been performed, but no reliable gene signature for prediction of CRC prognosis has been found. Bioinformatic enrichment tools are a powerful approach to identify biological processes in high-throughput data analysis.We have for the first time collected the results from the 23 so far published independent GEP studies on CRC prognosis. In these 23 studies, 1475 unique, mapped genes were identified, from which 124 (8.4%) were reported in at least two studies, with 54 of them showing consisting direction in expression change between the single studies. Using these data, we attempted to overcome the lack of reproducibility observed in the genes reported in individual GEP studies by carrying out a pathway-based enrichment analysis. We used up to ten tools for overrepresentation analysis of Gene Ontology (GO) categories or Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways in each of the three gene lists (1475, 124 and 54 genes). This strategy, based on testing multiple tools, allowed us to identify the oxidative phosphorylation chain and the extracellular matrix receptor interaction categories, as well as a general category related to cell proliferation and apoptosis, as the only significantly and consistently overrepresented pathways in the three gene lists, which were reported by several enrichment tools.Our pathway-based enrichment analysis of 23 independent gene expression profiling studies on prognosis of CRC identified significantly and consistently overrepresented prognostic categories for CRC. These overrepresented categories have been functionally clearly related with cancer progression, and deserve further investigation." @default.
• W2079249283 created "2016-06-24" @default.
• W2079249283 creator A5017796230 @default.
• W2079249283 creator A5079168261 @default.
• W2079249283 creator A5081163695 @default.
• W2079249283 creator A5090212645 @default.
• W2079249283 date "2011-04-25" @default.
• W2079249283 modified "2023-09-26" @default.
• W2079249283 title "Consensus Pathways Implicated in Prognosis of Colorectal Cancer Identified Through Systematic Enrichment Analysis of Gene Expression Profiling Studies" @default.
• W2079249283 cites W1974567967 @default.
• W2079249283 cites W1978514668 @default.
• W2079249283 cites W1980548655 @default.
• W2079249283 cites W1992143229 @default.
• W2079249283 cites W1998707409 @default.
• W2079249283 cites W2004703722 @default.
• W2079249283 cites W2005750374 @default.
• W2079249283 cites W2010136835 @default.
• W2079249283 cites W2021086569 @default.
• W2079249283 cites W2023458939 @default.
• W2079249283 cites W2029175285 @default.
• W2079249283 cites W2030025965 @default.
• W2079249283 cites W2033533336 @default.
• W2079249283 cites W2041413731 @default.
• W2079249283 cites W2041826036 @default.
• W2079249283 cites W2045729458 @default.
• W2079249283 cites W2049963771 @default.
• W2079249283 cites W2061566250 @default.
• W2079249283 cites W2063391460 @default.
• W2079249283 cites W2064231891 @default.
• W2079249283 cites W2070605698 @default.
• W2079249283 cites W2085971602 @default.
• W2079249283 cites W2087670505 @default.
• W2079249283 cites W2098179994 @default.
• W2079249283 cites W2099620553 @default.
• W2079249283 cites W2101136061 @default.
• W2079249283 cites W2103017472 @default.
• W2079249283 cites W2104488717 @default.
• W2079249283 cites W2105829583 @default.
• W2079249283 cites W2106089894 @default.
• W2079249283 cites W2114381883 @default.
• W2079249283 cites W2114739452 @default.
• W2079249283 cites W2133465414 @default.
• W2079249283 cites W2135230352 @default.
• W2079249283 cites W2138137742 @default.
• W2079249283 cites W2142101030 @default.
• W2079249283 cites W2142237411 @default.
• W2079249283 cites W2144330713 @default.
• W2079249283 cites W2146303969 @default.
• W2079249283 cites W2147000598 @default.
• W2079249283 cites W2148946492 @default.
• W2079249283 cites W2150853377 @default.
• W2079249283 cites W2153206163 @default.
• W2079249283 cites W2158217645 @default.
• W2079249283 cites W2163564081 @default.
• W2079249283 cites W4230792699 @default.
• W2079249283 cites W4243903519 @default.
• W2079249283 doi "https://doi.org/10.1371/journal.pone.0018867" @default.
• W2079249283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081819" @default.
• W2079249283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21541025" @default.
• W2079249283 hasPublicationYear "2011" @default.
• W2079249283 type Work @default.
• W2079249283 sameAs 2079249283 @default.
• W2079249283 citedByCount "32" @default.
• W2079249283 countsByYear W20792492832012 @default.
• W2079249283 countsByYear W20792492832013 @default.
• W2079249283 countsByYear W20792492832014 @default.
• W2079249283 countsByYear W20792492832015 @default.
• W2079249283 countsByYear W20792492832016 @default.
• W2079249283 countsByYear W20792492832017 @default.
• W2079249283 countsByYear W20792492832018 @default.
• W2079249283 countsByYear W20792492832020 @default.
• W2079249283 countsByYear W20792492832021 @default.
• W2079249283 countsByYear W20792492832022 @default.
• W2079249283 countsByYear W20792492832023 @default.
• W2079249283 crossrefType "journal-article" @default.
• W2079249283 hasAuthorship W2079249283A5017796230 @default.
• W2079249283 hasAuthorship W2079249283A5079168261 @default.
• W2079249283 hasAuthorship W2079249283A5081163695 @default.
• W2079249283 hasAuthorship W2079249283A5090212645 @default.
• W2079249283 hasBestOaLocation W20792492831 @default.
• W2079249283 hasConcept C104317684 @default.
• W2079249283 hasConcept C121608353 @default.
• W2079249283 hasConcept C150194340 @default.
• W2079249283 hasConcept C152724338 @default.
• W2079249283 hasConcept C165864922 @default.
• W2079249283 hasConcept C18431079 @default.
• W2079249283 hasConcept C2987395477 @default.
• W2079249283 hasConcept C526805850 @default.
• W2079249283 hasConcept C54355233 @default.
• W2079249283 hasConcept C60644358 @default.
• W2079249283 hasConcept C70721500 @default.
• W2079249283 hasConcept C86803240 @default.
• W2079249283 hasConcept C9927688 @default.
• W2079249283 hasConceptScore W2079249283C104317684 @default.
• W2079249283 hasConceptScore W2079249283C121608353 @default.
• W2079249283 hasConceptScore W2079249283C150194340 @default.
• W2079249283 hasConceptScore W2079249283C152724338 @default.
• W2079249283 hasConceptScore W2079249283C165864922 @default.

• next