Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079250887> ?p ?o ?g. }
- W2079250887 endingPage "418" @default.
- W2079250887 startingPage "410" @default.
- W2079250887 abstract "The objective of this study was to compare the in vitro and in vivo performance of rod shaped and spherical like nanocrystals for oral administration. Lovastatin (LOV) was chosen as the model drug and LOV rod shaped nanocrystals (LOV-RNs) and spherical like nanocrystals (LOV-SNs) were prepared by sonoprecipitation and bead milling, respectively. The dry powders obtained following freeze-drying were characterized by hydrodynamic diameter, polydispersity index, zeta potential, transmission electron microscope, scanning electron microscope, atomic force microscope, differential scanning calorimetry, Fourier transform infrared spectroscopy, and in vitro dissolution test. The pharmacokinetic study was performed in beagle dogs. The results obtained showed that LOV-RNs and LOV-SNs had similar hydrodynamic diameters (500.6 ± 21.0 nm versus 503.2 ± 20.4 nm), and the same crystalline state. The dissolution test showed that LOV-RNs had a higher dissolution rate than LOV-SNs. The AUC(0–24 h) values of LOV-RNs and LOV-SNs were higher than Junning® for both LOV (p < 0.05 for LOV-RNs, and p > 0.05 for LOV-SNs) and lovastatin acid (p > 0.05). More importantly, the oral bioavailability of LOV-RNs was higher than LOV-SNs (p > 0.05). The findings of this study show that the crystal shape has a significant effect on oral bioavailability." @default.
- W2079250887 created "2016-06-24" @default.
- W2079250887 creator A5006295324 @default.
- W2079250887 creator A5019330832 @default.
- W2079250887 creator A5032142693 @default.
- W2079250887 creator A5039743277 @default.
- W2079250887 creator A5053593250 @default.
- W2079250887 creator A5064323494 @default.
- W2079250887 creator A5075645933 @default.
- W2079250887 creator A5083614554 @default.
- W2079250887 date "2015-04-01" @default.
- W2079250887 modified "2023-10-10" @default.
- W2079250887 title "Rod shaped nanocrystals exhibit superior in vitro dissolution and in vivo bioavailability over spherical like nanocrystals: A case study of lovastatin" @default.
- W2079250887 cites W1608460191 @default.
- W2079250887 cites W1966982589 @default.
- W2079250887 cites W1967889734 @default.
- W2079250887 cites W1967935934 @default.
- W2079250887 cites W1968764209 @default.
- W2079250887 cites W1969644888 @default.
- W2079250887 cites W1975230163 @default.
- W2079250887 cites W1976764164 @default.
- W2079250887 cites W1977794743 @default.
- W2079250887 cites W1979400308 @default.
- W2079250887 cites W1981405716 @default.
- W2079250887 cites W1982935606 @default.
- W2079250887 cites W1985010122 @default.
- W2079250887 cites W1985868908 @default.
- W2079250887 cites W1991132940 @default.
- W2079250887 cites W1991916654 @default.
- W2079250887 cites W1993002471 @default.
- W2079250887 cites W2011707100 @default.
- W2079250887 cites W2018928551 @default.
- W2079250887 cites W2019984795 @default.
- W2079250887 cites W2021130493 @default.
- W2079250887 cites W2025265553 @default.
- W2079250887 cites W2028536670 @default.
- W2079250887 cites W2032890774 @default.
- W2079250887 cites W2034404481 @default.
- W2079250887 cites W2036223922 @default.
- W2079250887 cites W2038487017 @default.
- W2079250887 cites W2038850098 @default.
- W2079250887 cites W2040432233 @default.
- W2079250887 cites W2042633554 @default.
- W2079250887 cites W2050937940 @default.
- W2079250887 cites W2053334003 @default.
- W2079250887 cites W2056211275 @default.
- W2079250887 cites W2056520644 @default.
- W2079250887 cites W2057939348 @default.
- W2079250887 cites W2059225643 @default.
- W2079250887 cites W2063288695 @default.
- W2079250887 cites W2070561160 @default.
- W2079250887 cites W2071215562 @default.
- W2079250887 cites W2079465121 @default.
- W2079250887 cites W2088560132 @default.
- W2079250887 cites W2095016601 @default.
- W2079250887 cites W2098365084 @default.
- W2079250887 cites W2120377744 @default.
- W2079250887 cites W2141566507 @default.
- W2079250887 cites W2150601513 @default.
- W2079250887 cites W2159465632 @default.
- W2079250887 cites W2317782256 @default.
- W2079250887 cites W2321365258 @default.
- W2079250887 cites W59336656 @default.
- W2079250887 doi "https://doi.org/10.1016/j.colsurfb.2015.02.039" @default.
- W2079250887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25766921" @default.
- W2079250887 hasPublicationYear "2015" @default.
- W2079250887 type Work @default.
- W2079250887 sameAs 2079250887 @default.
- W2079250887 citedByCount "50" @default.
- W2079250887 countsByYear W20792508872015 @default.
- W2079250887 countsByYear W20792508872016 @default.
- W2079250887 countsByYear W20792508872017 @default.
- W2079250887 countsByYear W20792508872018 @default.
- W2079250887 countsByYear W20792508872019 @default.
- W2079250887 countsByYear W20792508872020 @default.
- W2079250887 countsByYear W20792508872021 @default.
- W2079250887 countsByYear W20792508872022 @default.
- W2079250887 countsByYear W20792508872023 @default.
- W2079250887 crossrefType "journal-article" @default.
- W2079250887 hasAuthorship W2079250887A5006295324 @default.
- W2079250887 hasAuthorship W2079250887A5019330832 @default.
- W2079250887 hasAuthorship W2079250887A5032142693 @default.
- W2079250887 hasAuthorship W2079250887A5039743277 @default.
- W2079250887 hasAuthorship W2079250887A5053593250 @default.
- W2079250887 hasAuthorship W2079250887A5064323494 @default.
- W2079250887 hasAuthorship W2079250887A5075645933 @default.
- W2079250887 hasAuthorship W2079250887A5083614554 @default.
- W2079250887 hasConcept C11432220 @default.
- W2079250887 hasConcept C127413603 @default.
- W2079250887 hasConcept C13965031 @default.
- W2079250887 hasConcept C146088050 @default.
- W2079250887 hasConcept C150903083 @default.
- W2079250887 hasConcept C155672457 @default.
- W2079250887 hasConcept C159985019 @default.
- W2079250887 hasConcept C160892712 @default.
- W2079250887 hasConcept C171250308 @default.
- W2079250887 hasConcept C175854130 @default.
- W2079250887 hasConcept C178790620 @default.