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- W2079251359 abstract "The activation of GABA receptor subtype A (GABAA) and GABA receptor subtype B (GABAB) receptors mediates differential effects on GABAergic and non-GABAergic transmission in the basal ganglia. To further characterize the anatomical substrate that underlies these functions, we used immunogold labeling to compare the subcellular and subsynaptic localization of GABAA and GABAB receptors in the subthalamic nucleus (STN). Our findings demonstrate major differences and some similarities in the distribution of GABAA and GABAB receptors in the monkey STN. The immunoreactivity for GABAA receptor α1 subunits is mostly bound to the plasma membrane, whereas GABAB R1 subunit α1 immunoreactivity is largely expressed intracellularly. Plasma membrane-bound GABAA α1 subunit aggregate in the main body of putative GABAergic synapses, while GABAB R1 receptors are found at the edges of putative glutamatergic or GABAergic synapses. A large pool of plasma membrane-bound GABAA and GABAB receptors is extrasynaptic. In conclusion, these findings demonstrate a significant degree of heterogeneity between the distributions of the two major GABA receptor subtypes in the monkey STN. Their pattern of synaptic localization puts forward interesting questions regarding their mechanisms of activation and functions at GABAergic and non-GABAergic synapses." @default.
- W2079251359 created "2016-06-24" @default.
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- W2079251359 creator A5051289855 @default.
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- W2079251359 date "2004-01-01" @default.
- W2079251359 modified "2023-10-18" @default.
- W2079251359 title "Differential subcellular and subsynaptic distribution of GABAA and GABAB receptors in the monkey subthalamic nucleus" @default.
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- W2079251359 doi "https://doi.org/10.1016/j.neuroscience.2004.05.014" @default.
- W2079251359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15283969" @default.
- W2079251359 hasPublicationYear "2004" @default.
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