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- W2079253925 endingPage "R244" @default.
- W2079253925 startingPage "R233" @default.
- W2079253925 abstract "Targeted therapy in oncology consists of drugs that specifically interfere with abnormal signaling pathways that are dysregulated in cancer cells. Tyrosine kinase inhibitors (TKIs) take advantage of unique oncogenes that are activated in certain types of cancer, and also target common mechanisms of growth, invasion, metastasis, and angiogenesis. However, many kinase inhibitors for cancer therapy are somewhat nonselective, and most have additional mechanisms of action at the cellular level, which are not completely understood. The use of these agents has increased our knowledge of important side effects, of which the practicing clinician must be aware. Recently, proposed endocrine-related side effects of these agents include alterations in thyroid function, bone metabolism, linear growth, gonadal function, fetal development, and glucose metabolism, and adrenal function. This review summarizes the most recent data on the endocrine side effects of TKIs." @default.
- W2079253925 created "2016-06-24" @default.
- W2079253925 creator A5031897654 @default.
- W2079253925 creator A5040742238 @default.
- W2079253925 date "2010-09-01" @default.
- W2079253925 modified "2023-10-12" @default.
- W2079253925 title "Endocrine side effects of broad-acting kinase inhibitors" @default.
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- W2079253925 doi "https://doi.org/10.1677/erc-10-0082" @default.
- W2079253925 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3039175" @default.
- W2079253925 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20603395" @default.
- W2079253925 hasPublicationYear "2010" @default.
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