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- W2079259521 abstract "Abstract We examine how synaptic depression resulting from desensitization (as modelled by a kinetic scheme for GABAA synapses), affects the coherent frequency produced by inhibitory networks. Analytical work using a phenomenological model of synaptic depression shows that different mechanisms are invoked in determining the synchronized frequency. Numerical simulations with the receptor desensitization model show that behaviours predicted by the analytical work are obtained when desensitization is modulated as occurs with anesthetics. Our results suggest that the coherent frequency of inhibitory networks is very sensitive to desensitization. Thus, the effects of different anesthetics on desensitization may contribute to their differential neurodepressive effects." @default.
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- W2079259521 date "2001-06-01" @default.
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- W2079259521 title "Frequency switches in inhibitory networks with anesthetics" @default.
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- W2079259521 doi "https://doi.org/10.1016/s0925-2312(01)00385-x" @default.
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