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- W2079260025 abstract "The majority of symptomatic uterine fibroids are currently treated by surgical interventions (myomectomy or hysterectomy) or radiological treatments (uterine artery embolisation or focussed ultrasound surgery). None of these treatments is a panacea, and what is conspicuous is the lack of an effective long-term medical therapy for a disorder so common among women of reproductive age. It has been known for some time that progesterone and its receptors enhance proliferative activity in fibroids and this has raised the possibility that anti-progestins and (PRMs) could be useful in the medical management of fibroids. Some of the compounds which have produced promising results in recent clinical trials or research studies include mifepristone, CDB-4124 (telapristone), CP-8947, J-867 (asoprisnil) and CDB-2914 (ulipristal acetate or UA). UA has recently completed Phase III clinical trials with very encouraging results, and has now acquired a licence for clinical use in Europe. While considerable research has yet to be done on the long-term safety and efficacy of UA there is nevertheless good reason for optimism on the emergence of effective medical therapy in the form of UA and possibly other PRMs." @default.
- W2079260025 created "2016-06-24" @default.
- W2079260025 creator A5010249392 @default.
- W2079260025 creator A5050443361 @default.
- W2079260025 date "2012-12-01" @default.
- W2079260025 modified "2023-09-23" @default.
- W2079260025 title "Progesterone and progesterone receptor modulators in the management of symptomatic uterine fibroids" @default.
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- W2079260025 doi "https://doi.org/10.1016/j.ejogrb.2012.07.023" @default.
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