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• W2079260075 abstract "Abstract A series of halogen‐containing alkylglycerolipid analogs has been checked for their cytostatic activity both in vitro and in vivo. The compounds included alkyldeoxyhaloglycerols (I), alkyldeoxyhaloglycerophosphocholines (II), and alkyldeoxyhaloglycerophosphoric acids and alkyl esters (III). While compounds I and III were moderately active, compounds II were found to have a strong inhibitory effect on the proliferation of Ehrlich ascites tumor cells in vitro. Cell growth inhibition of 50% or more was found mainly in the late S‐ or G 2 ‐phase of the cell cycle as revealed by flow cytometry. Alkyl lysophospholipid analogs II and cholesterol form liposomes with high encapsulation efficiency and low permeability for entrapped substances. Compounds II were active against Lewis lung carcinoma in mice when applied in free form or as liposomes." @default.
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• W2079260075 date "1987-11-01" @default.
• W2079260075 modified "2023-09-30" @default.
• W2079260075 title "Cytostatic activity of syntheticO-alkylglycerolipids" @default.
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• W2079260075 doi "https://doi.org/10.1007/bf02535551" @default.
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