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• W2079261726 abstract "PurposeRejection is one of the major causes of mortality in the first year after heart transplantation. Hospital readmission for this complication is also prevalent. It has not been established what risk factors have been studied as a risk for hospital admission for rejection.MethodsBetween 2004 and 2014 we evaluated 261 heart transplant patients for first year admissions due to severe rejection and assessed risk factors through multivariate analysis. The following risk factors were included in the multivariate analysis: age under 55, donor age less than 40, sex, ischemic time over 240 minutes, pre transplant PRA over 10%, hypertension, diabetes, and renal insufficiency.ResultsThrough multivariate analysis, age under 55 was associated with a 2.6-fold increase for risk of rejection hospitalization. This was significant after controlling for other risk factors. No other variables listed above had a significant impact on the risk of hospital admission for rejection.ConclusionHeart transplant recipients under 55 years are associated with a higher risk for hospital admission for severe rejection possibly due to a more active immune system and more medication non-compliance. More aggressive immune monitoring for rejection in these younger patients may be warranted to prevent this complication. PurposeRejection is one of the major causes of mortality in the first year after heart transplantation. Hospital readmission for this complication is also prevalent. It has not been established what risk factors have been studied as a risk for hospital admission for rejection. Rejection is one of the major causes of mortality in the first year after heart transplantation. Hospital readmission for this complication is also prevalent. It has not been established what risk factors have been studied as a risk for hospital admission for rejection. MethodsBetween 2004 and 2014 we evaluated 261 heart transplant patients for first year admissions due to severe rejection and assessed risk factors through multivariate analysis. The following risk factors were included in the multivariate analysis: age under 55, donor age less than 40, sex, ischemic time over 240 minutes, pre transplant PRA over 10%, hypertension, diabetes, and renal insufficiency. Between 2004 and 2014 we evaluated 261 heart transplant patients for first year admissions due to severe rejection and assessed risk factors through multivariate analysis. The following risk factors were included in the multivariate analysis: age under 55, donor age less than 40, sex, ischemic time over 240 minutes, pre transplant PRA over 10%, hypertension, diabetes, and renal insufficiency. ResultsThrough multivariate analysis, age under 55 was associated with a 2.6-fold increase for risk of rejection hospitalization. This was significant after controlling for other risk factors. No other variables listed above had a significant impact on the risk of hospital admission for rejection. Through multivariate analysis, age under 55 was associated with a 2.6-fold increase for risk of rejection hospitalization. This was significant after controlling for other risk factors. No other variables listed above had a significant impact on the risk of hospital admission for rejection. ConclusionHeart transplant recipients under 55 years are associated with a higher risk for hospital admission for severe rejection possibly due to a more active immune system and more medication non-compliance. More aggressive immune monitoring for rejection in these younger patients may be warranted to prevent this complication. Heart transplant recipients under 55 years are associated with a higher risk for hospital admission for severe rejection possibly due to a more active immune system and more medication non-compliance. More aggressive immune monitoring for rejection in these younger patients may be warranted to prevent this complication." @default.
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• W2079261726 date "2015-04-01" @default.
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• W2079261726 title "Risk Factors for Hospital Admissions for Rejection Following Heart Transplantation: The Real Story" @default.
• W2079261726 doi "https://doi.org/10.1016/j.healun.2015.01.843" @default.
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