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- W2079264336 abstract "Amyloid formation is a widespread feature of various proteins. It is associated with both important diseases (including infectious mammalian prions) and biologically positive functions, and provides a basis for structural “templating” and protein-based epigenetic inheritance (for example, in the case of yeast prions). Amyloid templating is characterized by a high level of sequence specificity and conformational fidelity. Even slight variations in sequence may produce a strong barrier for prion transmission. Yeast models provide useful insight into a mechanism of amyloid specificity and fidelity. Accumulating evidence indicates that cross-species prion transmission is controlled by the identity of short sequences (specificity stretches) rather than by the overall level of sequence identity. Location of the specificity stretches determines the location and/or size of the cross-β amyloid region that controls patterns of prion variants. In some cases of cross-species prion transmission, fidelity of variant reproduction is impaired, leading to the formation of new structural variants. We propose that such a variant switch may occur due to choice of the alternatively located secondary specificity stretches, when interaction between the primary stretches is impaired due to sequence divergence." @default.
- W2079264336 created "2016-06-24" @default.
- W2079264336 creator A5071260624 @default.
- W2079264336 creator A5082912822 @default.
- W2079264336 date "2011-07-01" @default.
- W2079264336 modified "2023-09-27" @default.
- W2079264336 title "Sequence specificity and fidelity of prion transmission in yeast" @default.
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- W2079264336 cites W1503622815 @default.
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- W2079264336 cites W1910034148 @default.
- W2079264336 cites W1913570942 @default.
- W2079264336 cites W1965851652 @default.
- W2079264336 cites W1969749769 @default.
- W2079264336 cites W1972358416 @default.
- W2079264336 cites W1973897761 @default.
- W2079264336 cites W1976201852 @default.
- W2079264336 cites W1978959047 @default.
- W2079264336 cites W1979575360 @default.
- W2079264336 cites W1985458353 @default.
- W2079264336 cites W1987553827 @default.
- W2079264336 cites W1989150559 @default.
- W2079264336 cites W1990383225 @default.
- W2079264336 cites W1992119552 @default.
- W2079264336 cites W1993027148 @default.
- W2079264336 cites W1994265362 @default.
- W2079264336 cites W1995246821 @default.
- W2079264336 cites W1995496955 @default.
- W2079264336 cites W2002332675 @default.
- W2079264336 cites W2002886872 @default.
- W2079264336 cites W2004559462 @default.
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- W2079264336 cites W2016829947 @default.
- W2079264336 cites W2025482639 @default.
- W2079264336 cites W2028728539 @default.
- W2079264336 cites W2036404841 @default.
- W2079264336 cites W2038004674 @default.
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- W2079264336 doi "https://doi.org/10.1016/j.semcdb.2011.03.005" @default.
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