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- W2079266227 abstract "Mutations in LRRK2 (leucine-rich repeat kinase 2) are found associated with both sporadic and familial Parkinson's disease (PD). Pathogenic mutations are localized to the catalytic domains of LRRK2, including kinase and GTPase domains. Altered catalytic activity correlates with neurotoxicity, indicating that targeting those activities may provide clues as to novel therapeutic strategies for LRRK2-linked PD. However, the cellular readout of such altered catalytic activities remains largely unknown. Recent cell biological studies have started to highlight possible early cellular events which are altered in the presence of pathogenic LRRK2 and may ultimately lead to neuronal demise, and these studies link altered LRRK2 function to various abnormal endolysosomal vesicular trafficking events. This review examines our current knowledge of LRRK2 neurobiology and how pathogenic mutations may lead to neurodegeneration in PD." @default.
- W2079266227 created "2016-06-24" @default.
- W2079266227 creator A5009372799 @default.
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- W2079266227 creator A5074073118 @default.
- W2079266227 creator A5090189628 @default.
- W2079266227 date "2014-10-01" @default.
- W2079266227 modified "2023-10-16" @default.
- W2079266227 title "Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease" @default.
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