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• W2079267913 abstract "Amlodipine has been shown to be effective in reducing blood pressure (BP) throughout the day and night when given once daily. However, the potential chronopharmacologic differing effects on BP of amlodipine have only been addressed occasionally. We investigated the administration time-dependent antihypertensive efficacy of amlodipine given as added therapy in hypertensive patients. We studied 87 patients with uncontrolled grade 1–2 essential hypertension (45 men), 54.4±12.2 years of age, who were already taken an average of 1.8 drugs (mainly an ARB or ACE inhibitor combined with a diuretic). Patients were randomly assigned to receive a single daily dose of amlodipine (5 mg/day) either on awakening or before bedtime. BP was monitored at 20-min intervals from 07:00 to 23:00 hours and at 30-min intervals at night for 48 consecutive hours at baseline and after 3 months of therapeutic intervention. Physical activity was simultaneously monitored every min by wrist actigraphy, and the information used to determine diurnal and nocturnal means of BP for each patient according to individual resting time. After amlodipine on awakening, the reduction in BP was highly statistically significant (8.6 and 5.6 mm Hg reduction in the 24-hour mean of systolic and diastolic BP, respectively; P<0.001). The BP reduction was equivalent after amlodipine before bedtime (9.4 and 5.9 mm Hg reduction in systolic and diastolic BP, respectively; P<0.001). This BP reduction was similar during both daytime activity and nighttime resting hours, independently of dosing time, indicating a 24-hour therapeutic coverage of amlodipine administered either on awakening or before bedtime. The day/night BP ratio was slightly reduced after morning treatment (−0.6 and –1.2 for systolic and diastolic BP), but increased after evening treatment (1.4 and 1.3, respectively), although differences between treatment-times were not significant (P=0.137). Results from this trial on uncontrolled hypertensive patients demonstrate that, independently of the time of administration with respect to the rest-activity cycle of each individual patient, a single daily dose of amlodipine efficiently reduces BP for the whole 24 hours of the day. The similar BP reduction observed for the diurnal and nocturnal means indicates that amlodipine does not modify the circadian pattern of BP variability. Am J Hypertens (2004) 17, 110A–110A; doi: 10.1016/j.amjhyper.2004.03.285" @default.
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• W2079267913 date "2004-05-01" @default.
• W2079267913 modified "2023-10-17" @default.
• W2079267913 title "Administration time-dependent effects on ambulatory blood pressure of amlodipine as added therapy in uncontrolled hypertensive patients" @default.
• W2079267913 doi "https://doi.org/10.1016/j.amjhyper.2004.03.285" @default.
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