Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079269324> ?p ?o ?g. }
- W2079269324 endingPage "e97144" @default.
- W2079269324 startingPage "e97144" @default.
- W2079269324 abstract "Diacylglycerol kinase α (DGKα), by phosphorylating diacylglycerol into phosphatidic acid, provides a key signal driving cell migration and matrix invasion. We previously demonstrated that in epithelial cells activation of DGKα activity promotes cytoskeletal remodeling and matrix invasion by recruiting atypical PKC at ruffling sites and by promoting RCP-mediated recycling of α5β1 integrin to the tip of pseudopods. In here we investigate the signaling pathway by which DGKα mediates SDF-1α-induced matrix invasion of MDA-MB-231 invasive breast carcinoma cells. Indeed we showed that, following SDF-1α stimulation, DGKα is activated and localized at cell protrusion, thus promoting their elongation and mediating SDF-1α induced MMP-9 metalloproteinase secretion and matrix invasion. Phosphatidic acid generated by DGKα promotes localization at cell protrusions of atypical PKCs which play an essential role downstream of DGKα by promoting Rac-mediated protrusion elongation and localized recruitment of β1 integrin and MMP-9. We finally demonstrate that activation of DGKα, atypical PKCs signaling and β1 integrin are all essential for MDA-MB-231 invasiveness. These data indicates the existence of a SDF-1α induced DGKα - atypical PKC - β1 integrin signaling pathway, which is essential for matrix invasion of carcinoma cells." @default.
- W2079269324 created "2016-06-24" @default.
- W2079269324 creator A5000948027 @default.
- W2079269324 creator A5002741949 @default.
- W2079269324 creator A5004004010 @default.
- W2079269324 creator A5009640354 @default.
- W2079269324 creator A5014108311 @default.
- W2079269324 creator A5020680542 @default.
- W2079269324 creator A5031664151 @default.
- W2079269324 creator A5032548159 @default.
- W2079269324 creator A5043399461 @default.
- W2079269324 creator A5043681007 @default.
- W2079269324 creator A5048760160 @default.
- W2079269324 creator A5051157302 @default.
- W2079269324 creator A5055926291 @default.
- W2079269324 creator A5057905121 @default.
- W2079269324 creator A5059172042 @default.
- W2079269324 creator A5062616618 @default.
- W2079269324 creator A5083101249 @default.
- W2079269324 creator A5085111107 @default.
- W2079269324 date "2014-06-02" @default.
- W2079269324 modified "2023-09-30" @default.
- W2079269324 title "The Diacylglycerol Kinase α/Atypical PKC/β1 Integrin Pathway in SDF-1α Mammary Carcinoma Invasiveness" @default.
- W2079269324 cites W146600679 @default.
- W2079269324 cites W1589994366 @default.
- W2079269324 cites W1920706136 @default.
- W2079269324 cites W1964021043 @default.
- W2079269324 cites W1972408555 @default.
- W2079269324 cites W1983798380 @default.
- W2079269324 cites W1986486541 @default.
- W2079269324 cites W1992767716 @default.
- W2079269324 cites W1994643099 @default.
- W2079269324 cites W2000546459 @default.
- W2079269324 cites W2001174679 @default.
- W2079269324 cites W2005334224 @default.
- W2079269324 cites W2007725137 @default.
- W2079269324 cites W2007956014 @default.
- W2079269324 cites W2023624246 @default.
- W2079269324 cites W2024850003 @default.
- W2079269324 cites W2030103715 @default.
- W2079269324 cites W2032188997 @default.
- W2079269324 cites W2041074472 @default.
- W2079269324 cites W2049471272 @default.
- W2079269324 cites W2054211644 @default.
- W2079269324 cites W2055791600 @default.
- W2079269324 cites W2056281268 @default.
- W2079269324 cites W2060185596 @default.
- W2079269324 cites W2072103796 @default.
- W2079269324 cites W2075729495 @default.
- W2079269324 cites W2077919059 @default.
- W2079269324 cites W2078344536 @default.
- W2079269324 cites W2079724447 @default.
- W2079269324 cites W2079880410 @default.
- W2079269324 cites W2082372996 @default.
- W2079269324 cites W2085424050 @default.
- W2079269324 cites W2086337788 @default.
- W2079269324 cites W2086790430 @default.
- W2079269324 cites W2087700852 @default.
- W2079269324 cites W2103972507 @default.
- W2079269324 cites W2104939091 @default.
- W2079269324 cites W2111264907 @default.
- W2079269324 cites W2113472355 @default.
- W2079269324 cites W2115899458 @default.
- W2079269324 cites W2117936690 @default.
- W2079269324 cites W2118397294 @default.
- W2079269324 cites W2127349963 @default.
- W2079269324 cites W2134773861 @default.
- W2079269324 cites W2142899629 @default.
- W2079269324 cites W2147000598 @default.
- W2079269324 cites W2147561113 @default.
- W2079269324 cites W2147599093 @default.
- W2079269324 cites W2156323704 @default.
- W2079269324 cites W2159141617 @default.
- W2079269324 cites W2166817392 @default.
- W2079269324 cites W4245201853 @default.
- W2079269324 doi "https://doi.org/10.1371/journal.pone.0097144" @default.
- W2079269324 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4041662" @default.
- W2079269324 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24887021" @default.
- W2079269324 hasPublicationYear "2014" @default.
- W2079269324 type Work @default.
- W2079269324 sameAs 2079269324 @default.
- W2079269324 citedByCount "30" @default.
- W2079269324 countsByYear W20792693242015 @default.
- W2079269324 countsByYear W20792693242016 @default.
- W2079269324 countsByYear W20792693242017 @default.
- W2079269324 countsByYear W20792693242018 @default.
- W2079269324 countsByYear W20792693242019 @default.
- W2079269324 countsByYear W20792693242020 @default.
- W2079269324 countsByYear W20792693242021 @default.
- W2079269324 countsByYear W20792693242022 @default.
- W2079269324 countsByYear W20792693242023 @default.
- W2079269324 crossrefType "journal-article" @default.
- W2079269324 hasAuthorship W2079269324A5000948027 @default.
- W2079269324 hasAuthorship W2079269324A5002741949 @default.
- W2079269324 hasAuthorship W2079269324A5004004010 @default.
- W2079269324 hasAuthorship W2079269324A5009640354 @default.
- W2079269324 hasAuthorship W2079269324A5014108311 @default.
- W2079269324 hasAuthorship W2079269324A5020680542 @default.