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- W2079272200 endingPage "2141" @default.
- W2079272200 startingPage "2125" @default.
- W2079272200 abstract "The preservation of myocyte number and cardiac mass throughout life is dependent on the balance between cell death and cell division. Rapidly emerging evidence indicates that new myocytes can be formed through the activation and differentiation of resident cardiac progenitor cells. The critical issue is the identification of mechanisms that define the aging of cardiac progenitor cells and, ultimately, their inability to replace dying myocytes. The most reliable marker of cellular senescence is the modification of the telomere-telomerase axis, together with the expression of the cell cycle inhibitors p16INK4a and p53. Cellular senescence is characterized by biochemical events that occur within the cell. In this regard, one of the most relevant processes is represented by repeated oxidative stress that may evolve into the activation of the cell death program or result in the development of a senescent phenotype. Thus, the modulation of telomerase activity and the control of telomeric length, together with the attenuation of the formation of reactive oxygen species, may represent important therapeutic tools in regenerative medicine and in prevention of aging and diabetic cardiomyopathies." @default.
- W2079272200 created "2016-06-24" @default.
- W2079272200 creator A5000452342 @default.
- W2079272200 creator A5008671980 @default.
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- W2079272200 creator A5022702109 @default.
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- W2079272200 creator A5067583378 @default.
- W2079272200 creator A5069585201 @default.
- W2079272200 creator A5072597913 @default.
- W2079272200 date "2006-11-01" @default.
- W2079272200 modified "2023-09-25" @default.
- W2079272200 title "The Telomere–Telomerase Axis and the Heart" @default.
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