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• W2079272639 abstract "Concentration dependence and reversibility of inhibition of rapid axonal transport by colchicine were correlated with morphological changes in rabbit vagus nerve. Influx of [14C]colchicine into the nerve was delayed by the presence of the nerve sheath, and inhibition of rapid transport took over twice as long as in desheathed nerves. Graded effects on transport of labeled protein were seen with 0.1–30 mM colchicine, associated with a progressive loss of microtubules. With 7.5 and 30 mM the number of neurofilaments increased. Inhibition of rapid transport was not reversed by washing for 3–20 h nor were the morphological effects. Conduction of the compound action potential was essentially unimpaired in all experiments. This contrasts with the effect of lidocaine, which blocks conduction as well as rapid transport reversibly and blocks rapid transport prior to affecting microtubule structure." @default.
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• W2079272639 date "1973-06-01" @default.
• W2079272639 modified "2023-09-23" @default.
• W2079272639 title "Dynamics of colchicine effects on rapid axonal transport and axonal morphology" @default.
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• W2079272639 doi "https://doi.org/10.1016/0006-8993(73)90343-0" @default.
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