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- W2079274504 abstract "During meiosis I, kinetochores of sister chromatids are juxtaposed or fused and mono-orient, while homologous chromosomes that are paired by chiasmata (bivalents) have to biorient. In the absence of chiasmata, biorientation of sister chromatids (univalents), which carries a risk of aneuploidy, has been occasionally detected in several species, including humans. We show in fission yeast that biorientation of fused sister kinetochores predominates during early prometaphase I. Without chiasmata, this undesirable biorientation of univalents persists and eventually evades the spindle assembly checkpoint, provoking abnormal anaphase. When univalents are connected by chiasmata or by an artificial tether, this erroneous attachment is converted to monopolar attachment and stabilized. This stabilization is apparently achieved by a chromosome configuration that brings kinetochores to the outer edge of the bivalent, while bringing Aurora B, a destabilizer of kinetochore-microtubule attachment, inward. Our results elucidate how chiasmata favor biorientation of bivalents over that of univalents at meiosis I." @default.
- W2079274504 created "2016-06-24" @default.
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- W2079274504 date "2011-09-01" @default.
- W2079274504 modified "2023-10-18" @default.
- W2079274504 title "Repositioning of Aurora B Promoted by Chiasmata Ensures Sister Chromatid Mono-Orientation in Meiosis I" @default.
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- W2079274504 doi "https://doi.org/10.1016/j.devcel.2011.08.012" @default.
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