FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079283237> ?p ?o ?g. }

• W2079283237 endingPage "208" @default.
• W2079283237 startingPage "203" @default.
• W2079283237 abstract "Caffeine, a nonspecific adenosine receptor (AR) antagonist is widely used to treat apnea of prematurity. Because adenosine modulates multiple biologic processes including inflammation, we hypothesized that AR blockade by caffeine would increase cytokine release from neonatal monocytes. Using cord blood monocytes (CBM), we investigated 1) the changes in AR mRNA profile by real time quantitative reverse-transcription polymerase-chain-reaction (qRT-PCR) and protein expression (western blot) after in vitro culture, caffeine or lipopolysaccharide (LPS) exposure, and 2) the modulation of cytokine release and cyclic adenosine monophosphate (cAMP) production by enzyme-linked immunosorbent assay (ELISA) induced by caffeine and specific AR antagonists: DPCPX(A1R), ZM241385(A2aR), MRS1754(A2bR), and MRS1220(A3R). After 48 h in culture, A2aR and A2bR gene expression increased 1.9 (p = 0.04) and 2.5-fold (p = 0.003), respectively. A1R protein expression directly correlated with increasing LPS concentrations (p = 0.01), with minimal expression preexposure. Only caffeine (50 μM) and DPCPX (10 nM) decreased tumor necrosis factor-alpha (TNF-α) release from LPS activated-CBM by 20 and 25% (p = 0.01) and TNF-α gene expression by 30 and 50%, respectively, in conjunction with a ≥2-fold increase in cAMP (p < 0.05). AR blockade did not modulate other measured cytokines. The induction of A1R after LPS exposure suggests an important role of this receptor in the control of inflammation in neonates. Our findings also suggest that caffeine, via A1R blockade, increases cAMP production and inhibits pretranscriptional TNF-α production by CBM." @default.
• W2079283237 created "2016-06-24" @default.
• W2079283237 creator A5006874734 @default.
• W2079283237 creator A5008209961 @default.
• W2079283237 creator A5013838174 @default.
• W2079283237 creator A5023220088 @default.
• W2079283237 creator A5083291881 @default.
• W2079283237 creator A5087128759 @default.
• W2079283237 date "2009-02-01" @default.
• W2079283237 modified "2023-10-15" @default.
• W2079283237 title "Caffeine Modulates TNF-α Production by Cord Blood Monocytes: The Role of Adenosine Receptors" @default.
• W2079283237 cites W1599185640 @default.
• W2079283237 cites W1944355206 @default.
• W2079283237 cites W1965554200 @default.
• W2079283237 cites W1969170402 @default.
• W2079283237 cites W1969866442 @default.
• W2079283237 cites W1970027494 @default.
• W2079283237 cites W1972180267 @default.
• W2079283237 cites W1986921326 @default.
• W2079283237 cites W2006285758 @default.
• W2079283237 cites W2018122001 @default.
• W2079283237 cites W2029551841 @default.
• W2079283237 cites W2048800299 @default.
• W2079283237 cites W2052143676 @default.
• W2079283237 cites W2059153581 @default.
• W2079283237 cites W2060953719 @default.
• W2079283237 cites W2062922526 @default.
• W2079283237 cites W2070082698 @default.
• W2079283237 cites W2076596205 @default.
• W2079283237 cites W2084593992 @default.
• W2079283237 cites W2085403057 @default.
• W2079283237 cites W2088746083 @default.
• W2079283237 cites W2092036055 @default.
• W2079283237 cites W2092941406 @default.
• W2079283237 cites W2102209677 @default.
• W2079283237 cites W2108244474 @default.
• W2079283237 cites W2114235313 @default.
• W2079283237 cites W2122319524 @default.
• W2079283237 cites W2130249957 @default.
• W2079283237 cites W2136365746 @default.
• W2079283237 cites W2163183512 @default.
• W2079283237 cites W2163203533 @default.
• W2079283237 cites W2166285615 @default.
• W2079283237 cites W4232408499 @default.
• W2079283237 doi "https://doi.org/10.1203/pdr.0b013e31818d66b1" @default.
• W2079283237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19047957" @default.
• W2079283237 hasPublicationYear "2009" @default.
• W2079283237 type Work @default.
• W2079283237 sameAs 2079283237 @default.
• W2079283237 citedByCount "77" @default.
• W2079283237 countsByYear W20792832372012 @default.
• W2079283237 countsByYear W20792832372013 @default.
• W2079283237 countsByYear W20792832372014 @default.
• W2079283237 countsByYear W20792832372015 @default.
• W2079283237 countsByYear W20792832372016 @default.
• W2079283237 countsByYear W20792832372017 @default.
• W2079283237 countsByYear W20792832372018 @default.
• W2079283237 countsByYear W20792832372019 @default.
• W2079283237 countsByYear W20792832372020 @default.
• W2079283237 countsByYear W20792832372021 @default.
• W2079283237 countsByYear W20792832372022 @default.
• W2079283237 countsByYear W20792832372023 @default.
• W2079283237 crossrefType "journal-article" @default.
• W2079283237 hasAuthorship W2079283237A5006874734 @default.
• W2079283237 hasAuthorship W2079283237A5008209961 @default.
• W2079283237 hasAuthorship W2079283237A5013838174 @default.
• W2079283237 hasAuthorship W2079283237A5023220088 @default.
• W2079283237 hasAuthorship W2079283237A5083291881 @default.
• W2079283237 hasAuthorship W2079283237A5087128759 @default.
• W2079283237 hasBestOaLocation W20792832371 @default.
• W2079283237 hasConcept C126322002 @default.
• W2079283237 hasConcept C134018914 @default.
• W2079283237 hasConcept C158424129 @default.
• W2079283237 hasConcept C170493617 @default.
• W2079283237 hasConcept C17991360 @default.
• W2079283237 hasConcept C182683403 @default.
• W2079283237 hasConcept C2776991684 @default.
• W2079283237 hasConcept C2778500429 @default.
• W2079283237 hasConcept C2778690821 @default.
• W2079283237 hasConcept C2778754761 @default.
• W2079283237 hasConcept C2778938600 @default.
• W2079283237 hasConcept C67907053 @default.
• W2079283237 hasConcept C71924100 @default.
• W2079283237 hasConcept C98274493 @default.
• W2079283237 hasConceptScore W2079283237C126322002 @default.
• W2079283237 hasConceptScore W2079283237C134018914 @default.
• W2079283237 hasConceptScore W2079283237C158424129 @default.
• W2079283237 hasConceptScore W2079283237C170493617 @default.
• W2079283237 hasConceptScore W2079283237C17991360 @default.
• W2079283237 hasConceptScore W2079283237C182683403 @default.
• W2079283237 hasConceptScore W2079283237C2776991684 @default.
• W2079283237 hasConceptScore W2079283237C2778500429 @default.
• W2079283237 hasConceptScore W2079283237C2778690821 @default.
• W2079283237 hasConceptScore W2079283237C2778754761 @default.
• W2079283237 hasConceptScore W2079283237C2778938600 @default.
• W2079283237 hasConceptScore W2079283237C67907053 @default.
• W2079283237 hasConceptScore W2079283237C71924100 @default.
• W2079283237 hasConceptScore W2079283237C98274493 @default.

• next