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• W2079288041 startingPage "4032" @default.
• W2079288041 abstract "This paper proposes an approach for increasing drug release durations from contact lenses and other biomedical devices by in situ creation of transport barriers of Vitamin E that force drug molecules to diffuse through long tortuous path. Results show that the increase in release duration is quadratic in Vitamin E loading, which is consistent with proposed mathematical models. Loadings of 10 and 40% Vitamin E increase release time of timolol by a factor of about 5 and 400, respectively for NIGHT&DAY™ lens. Similar results have been obtained for other hydrophilic drugs including fluconazole and dexamethasone 21-disodium phosphate (DXP). Vitamin E loading in the NIGHT&DAY™ lens leads to slight increase in lens sizes (6.5% increase for 30% loading), a slight reduction in oxygen diffusion (about 40% reduction for 75% loading), and a more significant reduction in the ion permeability (50% reduction for 10% loading). Additionally, Vitamin E loading has a beneficial effect of blocking UV radiation which will reduce the corneal damage due to UV light." @default.
• W2079288041 created "2016-06-24" @default.
• W2079288041 creator A5028439881 @default.
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• W2079288041 date "2010-05-01" @default.
• W2079288041 modified "2023-10-08" @default.
• W2079288041 title "Extended delivery of hydrophilic drugs from silicone-hydrogel contact lenses containing Vitamin E diffusion barriers" @default.
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• W2079288041 doi "https://doi.org/10.1016/j.biomaterials.2010.01.113" @default.
• W2079288041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20153894" @default.
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