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• W2079289675 abstract "Almost a century has passed since the first use of EEG to monitor electrophysiologic activity in the brain, and since the 1950s it has been the primary diagnostic modality for epilepsy. The scalp EEG, recorded through surface electrodes, characterizes both normal electrical activity in various frequency bands and global or focal paroxysmal activity of various kinds, including spikes, sharp waves, epileptiform discharges, and other rhythmic changes. EEG recordings have excellent temporal resolution, resolving spike activity lasting less than 100 μsec. Because of the physical location of the electrodes, however, thalamocortical and reticulocortical circuits dominate the EEG, and thus the spatial resolution is relatively poor, on the order of several centimeters.MRI, in clinical use for approximately a quarter of a century, provided unprecedented spatial resolution for structural abnormalities in the brain. Like EEG, MRI is noninvasive. MRI contributes substantially to the diagnosis and management of epilepsy by visualizing structural lesions that are putative seizure foci. As the sensitivity and spatial resolution of MRI improved, ever smaller and diverse structural changes can be identified. Over the past decade or so, clinicians and researchers recognized that MRI can detect subtle alterations in regional hemodynamics consequent to changes in regional brain function. While functional MRI (fMRI) is valuable primarily for the mapping of sensorimotor and cognitive functions, early clinical applications included the localization of epileptic phenomena.1,2 Although not yet at the spatial resolution of structural MRI, fMRI still provides the best spatial resolution of any noninvasive functional imaging modality at around 1 to 10 mm. However, because hemodynamic effects in regional brain activation occur over several seconds, the temporal resolution of fMRI is poor.An enticing goal in neuroimaging is to capitalize on the complementary strengths of EEG and fMRI, combining the excellent temporal resolution of EEG with the excellent spatial resolution …" @default.
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• W2079289675 date "2005-04-11" @default.
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• W2079289675 title "A multilayered approach to studying cortical malformations: EEG-fMRI" @default.
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