FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079292244> ?p ?o ?g. }

• W2079292244 endingPage "399" @default.
• W2079292244 startingPage "388" @default.
• W2079292244 abstract "Temporins are a family of short antimicrobial peptides (8-17 residues) that mostly show potent activity against Gram-positive bacteria. Herein, we demonstrate that temporin-SHd, a 17-residue peptide with a net charge of +2 (FLPAALAGIGGILGKLF(amide)), expressed a broad spectrum of antimicrobial activity. This peptide displayed potent antibacterial activities against Gram-negative and Gram-positive bacteria, including multi-drug resistant Staphylococcus aureus strains, as well as antiparasitic activity against promastigote and the intracellular stage (amastigote) of Leishmania infantum, at concentration not toxic for the macrophages. Temporin-SHd that is structured in a non-amphipathic α-helix in anionic membrane-mimetic environments, strongly and selectively perturbs anionic bilayer membranes by interacting with the polar head groups and acyl region of the phospholipids, with formation of regions of two coexisting phases: one phase rich in peptide and the other lipid-rich. The disruption of lipid packing within the bilayer may lead to the formation of transient pores and membrane permeation/disruption once a threshold peptide accumulation is reached. To our knowledge, Temporin-SHd represents the first known 17-residue long temporin expressing such broad spectrum of antimicrobial activity including members of the trypanosomatidae family. Additionally, since only a few shorter members (13 residues) of the temporin family are known to display antileishmanial activity (temporins-TA, -TB and -SHa), SHd is an interesting tool to analyze the antiparasitic mechanism of action of temporins." @default.
• W2079292244 created "2016-06-24" @default.
• W2079292244 creator A5003299717 @default.
• W2079292244 creator A5010104738 @default.
• W2079292244 creator A5024969922 @default.
• W2079292244 creator A5032543215 @default.
• W2079292244 creator A5036161938 @default.
• W2079292244 creator A5055072447 @default.
• W2079292244 creator A5077536062 @default.
• W2079292244 creator A5086683190 @default.
• W2079292244 creator A5091678548 @default.
• W2079292244 date "2013-02-01" @default.
• W2079292244 modified "2023-10-16" @default.
• W2079292244 title "Antibacterial and leishmanicidal activities of temporin-SHd, a 17-residue long membrane-damaging peptide" @default.
• W2079292244 cites W1482180296 @default.
• W2079292244 cites W1552825446 @default.
• W2079292244 cites W1568327448 @default.
• W2079292244 cites W1963968251 @default.
• W2079292244 cites W1964436136 @default.
• W2079292244 cites W1965431809 @default.
• W2079292244 cites W1968881741 @default.
• W2079292244 cites W1969316347 @default.
• W2079292244 cites W1973181432 @default.
• W2079292244 cites W1973643378 @default.
• W2079292244 cites W1974939251 @default.
• W2079292244 cites W1975076212 @default.
• W2079292244 cites W1982108884 @default.
• W2079292244 cites W1983003632 @default.
• W2079292244 cites W1983521156 @default.
• W2079292244 cites W1983697287 @default.
• W2079292244 cites W1984129808 @default.
• W2079292244 cites W1990069881 @default.
• W2079292244 cites W1990407294 @default.
• W2079292244 cites W1990823788 @default.
• W2079292244 cites W2001085474 @default.
• W2079292244 cites W2004369722 @default.
• W2079292244 cites W2007533585 @default.
• W2079292244 cites W2007552089 @default.
• W2079292244 cites W2007650837 @default.
• W2079292244 cites W2008030275 @default.
• W2079292244 cites W2015889658 @default.
• W2079292244 cites W2019513270 @default.
• W2079292244 cites W2020465942 @default.
• W2079292244 cites W2030299761 @default.
• W2079292244 cites W2034437921 @default.
• W2079292244 cites W2039692969 @default.
• W2079292244 cites W2044993462 @default.
• W2079292244 cites W2048411855 @default.
• W2079292244 cites W2052332240 @default.
• W2079292244 cites W2060486005 @default.
• W2079292244 cites W2062133476 @default.
• W2079292244 cites W2063036753 @default.
• W2079292244 cites W2063539703 @default.
• W2079292244 cites W2065576968 @default.
• W2079292244 cites W2065625464 @default.
• W2079292244 cites W2068934053 @default.
• W2079292244 cites W2074634660 @default.
• W2079292244 cites W2081624996 @default.
• W2079292244 cites W2093681609 @default.
• W2079292244 cites W2109803080 @default.
• W2079292244 cites W2110768169 @default.
• W2079292244 cites W2114526613 @default.
• W2079292244 cites W2119993590 @default.
• W2079292244 cites W2126452045 @default.
• W2079292244 cites W2130506152 @default.
• W2079292244 cites W2131953234 @default.
• W2079292244 cites W2133422002 @default.
• W2079292244 cites W2170912840 @default.
• W2079292244 cites W2410657835 @default.
• W2079292244 cites W3133382011 @default.
• W2079292244 cites W4292078949 @default.
• W2079292244 doi "https://doi.org/10.1016/j.biochi.2012.10.015" @default.
• W2079292244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23116712" @default.
• W2079292244 hasPublicationYear "2013" @default.
• W2079292244 type Work @default.
• W2079292244 sameAs 2079292244 @default.
• W2079292244 citedByCount "41" @default.
• W2079292244 countsByYear W20792922442013 @default.
• W2079292244 countsByYear W20792922442014 @default.
• W2079292244 countsByYear W20792922442015 @default.
• W2079292244 countsByYear W20792922442016 @default.
• W2079292244 countsByYear W20792922442017 @default.
• W2079292244 countsByYear W20792922442018 @default.
• W2079292244 countsByYear W20792922442019 @default.
• W2079292244 countsByYear W20792922442020 @default.
• W2079292244 countsByYear W20792922442021 @default.
• W2079292244 countsByYear W20792922442022 @default.
• W2079292244 countsByYear W20792922442023 @default.
• W2079292244 crossrefType "journal-article" @default.
• W2079292244 hasAuthorship W2079292244A5003299717 @default.
• W2079292244 hasAuthorship W2079292244A5010104738 @default.
• W2079292244 hasAuthorship W2079292244A5024969922 @default.
• W2079292244 hasAuthorship W2079292244A5032543215 @default.
• W2079292244 hasAuthorship W2079292244A5036161938 @default.
• W2079292244 hasAuthorship W2079292244A5055072447 @default.
• W2079292244 hasAuthorship W2079292244A5077536062 @default.
• W2079292244 hasAuthorship W2079292244A5086683190 @default.
• W2079292244 hasAuthorship W2079292244A5091678548 @default.

• next