Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079292785> ?p ?o ?g. }
- W2079292785 endingPage "968" @default.
- W2079292785 startingPage "958" @default.
- W2079292785 abstract "Anti-inflammatory therapy approaches have been in the focus of attention in the treatment of neurodegenerative diseases, such as Alzheimer's disease (AD). In this study, we examined the role of new 1,2,4-triazine derivatives against cytotoxicity exerted by lipopolysaccharide (LPS) in differentiated rat pheochromocytoma (PC12) cell line. Our results indicated that LPS-induced cell death can be inhibited in the presence of some of these compounds, as measured by MTT test, acridine orange/ethidium bromide staining and caspase-3 expression assay. We further showed that these compounds exert their protective effects through the inhibition of LPS-induced generation of nitric oxide and reactive oxygen species. Triazine derivatives inhibited LPS-induced nuclear translocation of nuclear factor- κB, a known regulator of a host of genes involved in specific stress and inflammatory responses. Pretreatment of PC12 cells with triazine derivatives also suppressed LPS-induced cyclooxygenase-2 expression while up-regulated heat shock protein-70 (Hsp-70). Moreover, the treatment of brain diseases is limited by the insufficiency in delivering therapeutic drugs into brain relating to highly limited transport of compounds through blood–brain barrier (BBB). Using a reliable model based on the artificial neural network, we indicated that these compounds are capable of penetrating BBB and may be useful agents for preventing neuroinflammatory diseases like AD." @default.
- W2079292785 created "2016-06-24" @default.
- W2079292785 creator A5000848039 @default.
- W2079292785 creator A5015899892 @default.
- W2079292785 creator A5027099936 @default.
- W2079292785 creator A5030045562 @default.
- W2079292785 creator A5036458420 @default.
- W2079292785 creator A5048950502 @default.
- W2079292785 creator A5060038619 @default.
- W2079292785 date "2010-12-01" @default.
- W2079292785 modified "2023-09-27" @default.
- W2079292785 title "Inhibition of LPS-induced apoptosis in differentiated-PC12 cells by new triazine derivatives through NF-κB-mediated suppression of COX-2" @default.
- W2079292785 cites W1506446734 @default.
- W2079292785 cites W1506914739 @default.
- W2079292785 cites W1585640564 @default.
- W2079292785 cites W1972812487 @default.
- W2079292785 cites W1974305753 @default.
- W2079292785 cites W1976164254 @default.
- W2079292785 cites W1979520552 @default.
- W2079292785 cites W1980768491 @default.
- W2079292785 cites W1989067276 @default.
- W2079292785 cites W1990985572 @default.
- W2079292785 cites W1992175732 @default.
- W2079292785 cites W1993019857 @default.
- W2079292785 cites W1996370639 @default.
- W2079292785 cites W2000880482 @default.
- W2079292785 cites W2003198698 @default.
- W2079292785 cites W2005186288 @default.
- W2079292785 cites W2014965141 @default.
- W2079292785 cites W2017688841 @default.
- W2079292785 cites W2018872680 @default.
- W2079292785 cites W2024991882 @default.
- W2079292785 cites W2033581608 @default.
- W2079292785 cites W2039453997 @default.
- W2079292785 cites W2044498513 @default.
- W2079292785 cites W2069810984 @default.
- W2079292785 cites W2070574603 @default.
- W2079292785 cites W2072925339 @default.
- W2079292785 cites W2094864822 @default.
- W2079292785 cites W2099157718 @default.
- W2079292785 cites W2110496967 @default.
- W2079292785 cites W2116561176 @default.
- W2079292785 cites W2119526249 @default.
- W2079292785 cites W2126305917 @default.
- W2079292785 cites W2126676163 @default.
- W2079292785 cites W2127161627 @default.
- W2079292785 cites W2128635872 @default.
- W2079292785 cites W2141353931 @default.
- W2079292785 cites W2156015902 @default.
- W2079292785 cites W2158303359 @default.
- W2079292785 cites W2165626477 @default.
- W2079292785 cites W2167963612 @default.
- W2079292785 cites W2168110247 @default.
- W2079292785 cites W2169097245 @default.
- W2079292785 cites W2171216596 @default.
- W2079292785 cites W2180058672 @default.
- W2079292785 cites W2415661443 @default.
- W2079292785 cites W2949452700 @default.
- W2079292785 cites W2949804276 @default.
- W2079292785 cites W40568358 @default.
- W2079292785 doi "https://doi.org/10.1016/j.neuint.2010.10.002" @default.
- W2079292785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20946929" @default.
- W2079292785 hasPublicationYear "2010" @default.
- W2079292785 type Work @default.
- W2079292785 sameAs 2079292785 @default.
- W2079292785 citedByCount "26" @default.
- W2079292785 countsByYear W20792927852012 @default.
- W2079292785 countsByYear W20792927852013 @default.
- W2079292785 countsByYear W20792927852014 @default.
- W2079292785 countsByYear W20792927852015 @default.
- W2079292785 countsByYear W20792927852017 @default.
- W2079292785 countsByYear W20792927852019 @default.
- W2079292785 countsByYear W20792927852020 @default.
- W2079292785 countsByYear W20792927852021 @default.
- W2079292785 countsByYear W20792927852022 @default.
- W2079292785 crossrefType "journal-article" @default.
- W2079292785 hasAuthorship W2079292785A5000848039 @default.
- W2079292785 hasAuthorship W2079292785A5015899892 @default.
- W2079292785 hasAuthorship W2079292785A5027099936 @default.
- W2079292785 hasAuthorship W2079292785A5030045562 @default.
- W2079292785 hasAuthorship W2079292785A5036458420 @default.
- W2079292785 hasAuthorship W2079292785A5048950502 @default.
- W2079292785 hasAuthorship W2079292785A5060038619 @default.
- W2079292785 hasConcept C109316439 @default.
- W2079292785 hasConcept C178790620 @default.
- W2079292785 hasConcept C185592680 @default.
- W2079292785 hasConcept C190283241 @default.
- W2079292785 hasConcept C202751555 @default.
- W2079292785 hasConcept C203014093 @default.
- W2079292785 hasConcept C2775975398 @default.
- W2079292785 hasConcept C2776151105 @default.
- W2079292785 hasConcept C2776914184 @default.
- W2079292785 hasConcept C2777730290 @default.
- W2079292785 hasConcept C2778754761 @default.
- W2079292785 hasConcept C2779102032 @default.
- W2079292785 hasConcept C2779830541 @default.
- W2079292785 hasConcept C48349386 @default.
- W2079292785 hasConcept C519581460 @default.