FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079294958> ?p ?o ?g. }

• W2079294958 endingPage "1103" @default.
• W2079294958 startingPage "1096" @default.
• W2079294958 abstract "IntroductionEpidermal growth factor receptor (EGFR) mutations are strong determinants of tumor response to EGFR tyrosine kinase inhibitors in non-small cell lung cancers (NSCLCs). Currently available methods of EGFR mutation detection rely on direct sequencing. Here, we describe the use of an alternative way to screen EGFR mutations.MethodsA total of 109 frozen tumor specimens from NSCLC patients were obtained. For mutational analysis of EGFR exons 18, 19, and 21, reverse transcription-polymerase chain reaction was performed on the cDNA using original primers designed for restriction fragment length polymorphism (RFLP).ResultsEGFR mutations were detected in 37 patients (34%) by both RFLP and direct sequencing except one case in which it was detected only by RFLP. EGFR mutations were more frequently observed to be significant by multivariate analysis in patients with adenocarcinoma (OR = 5.56), no-smoking history (OR = 4.34), and 65-year-old or younger (OR = 2.64), but not in women (OR = 1.14). Among 37 patients, 18 were treated with gefitinib and 9 responded to the treatment. One patient without any mutation responded.ConclusionRFLP is a useful method for screening EGFR mutations and can also be applied to predicting the sensitivity of NSCLC patients to EGFR-tyrosine kinase inhibitors." @default.
• W2079294958 created "2016-06-24" @default.
• W2079294958 creator A5012338301 @default.
• W2079294958 creator A5018712381 @default.
• W2079294958 creator A5018836964 @default.
• W2079294958 creator A5024413045 @default.
• W2079294958 creator A5026137348 @default.
• W2079294958 creator A5033715877 @default.
• W2079294958 creator A5038270737 @default.
• W2079294958 creator A5060272996 @default.
• W2079294958 creator A5075271142 @default.
• W2079294958 creator A5088002604 @default.
• W2079294958 date "2008-10-01" @default.
• W2079294958 modified "2023-10-16" @default.
• W2079294958 title "An Alternative Method for Screening EGFR Mutation Using RFLP in Non-small Cell Lung Cancer Patients" @default.
• W2079294958 cites W1973124093 @default.
• W2079294958 cites W2002937040 @default.
• W2079294958 cites W2003984225 @default.
• W2079294958 cites W2010397777 @default.
• W2079294958 cites W2016710415 @default.
• W2079294958 cites W2020779524 @default.
• W2079294958 cites W2043696829 @default.
• W2079294958 cites W2056034493 @default.
• W2079294958 cites W2080847394 @default.
• W2079294958 cites W2114642822 @default.
• W2079294958 cites W2117036891 @default.
• W2079294958 cites W2125195105 @default.
• W2079294958 cites W2128165330 @default.
• W2079294958 cites W2135619328 @default.
• W2079294958 cites W2139236349 @default.
• W2079294958 cites W2140775102 @default.
• W2079294958 cites W2143171062 @default.
• W2079294958 cites W2160040938 @default.
• W2079294958 cites W2161821474 @default.
• W2079294958 cites W2165119042 @default.
• W2079294958 cites W2167010023 @default.
• W2079294958 cites W2168841302 @default.
• W2079294958 cites W2170083676 @default.
• W2079294958 doi "https://doi.org/10.1097/jto.0b013e318186fadd" @default.
• W2079294958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18827604" @default.
• W2079294958 hasPublicationYear "2008" @default.
• W2079294958 type Work @default.
• W2079294958 sameAs 2079294958 @default.
• W2079294958 citedByCount "40" @default.
• W2079294958 countsByYear W20792949582012 @default.
• W2079294958 countsByYear W20792949582013 @default.
• W2079294958 countsByYear W20792949582014 @default.
• W2079294958 countsByYear W20792949582015 @default.
• W2079294958 countsByYear W20792949582016 @default.
• W2079294958 countsByYear W20792949582017 @default.
• W2079294958 countsByYear W20792949582018 @default.
• W2079294958 countsByYear W20792949582019 @default.
• W2079294958 countsByYear W20792949582021 @default.
• W2079294958 countsByYear W20792949582023 @default.
• W2079294958 crossrefType "journal-article" @default.
• W2079294958 hasAuthorship W2079294958A5012338301 @default.
• W2079294958 hasAuthorship W2079294958A5018712381 @default.
• W2079294958 hasAuthorship W2079294958A5018836964 @default.
• W2079294958 hasAuthorship W2079294958A5024413045 @default.
• W2079294958 hasAuthorship W2079294958A5026137348 @default.
• W2079294958 hasAuthorship W2079294958A5033715877 @default.
• W2079294958 hasAuthorship W2079294958A5038270737 @default.
• W2079294958 hasAuthorship W2079294958A5060272996 @default.
• W2079294958 hasAuthorship W2079294958A5075271142 @default.
• W2079294958 hasAuthorship W2079294958A5088002604 @default.
• W2079294958 hasBestOaLocation W20792949581 @default.
• W2079294958 hasConcept C104317684 @default.
• W2079294958 hasConcept C121608353 @default.
• W2079294958 hasConcept C126322002 @default.
• W2079294958 hasConcept C143998085 @default.
• W2079294958 hasConcept C168007829 @default.
• W2079294958 hasConcept C170493617 @default.
• W2079294958 hasConcept C2776256026 @default.
• W2079294958 hasConcept C2779438470 @default.
• W2079294958 hasConcept C2780580887 @default.
• W2079294958 hasConcept C2781182431 @default.
• W2079294958 hasConcept C36823959 @default.
• W2079294958 hasConcept C42362537 @default.
• W2079294958 hasConcept C49105822 @default.
• W2079294958 hasConcept C501734568 @default.
• W2079294958 hasConcept C502942594 @default.
• W2079294958 hasConcept C54355233 @default.
• W2079294958 hasConcept C71924100 @default.
• W2079294958 hasConcept C86803240 @default.
• W2079294958 hasConceptScore W2079294958C104317684 @default.
• W2079294958 hasConceptScore W2079294958C121608353 @default.
• W2079294958 hasConceptScore W2079294958C126322002 @default.
• W2079294958 hasConceptScore W2079294958C143998085 @default.
• W2079294958 hasConceptScore W2079294958C168007829 @default.
• W2079294958 hasConceptScore W2079294958C170493617 @default.
• W2079294958 hasConceptScore W2079294958C2776256026 @default.
• W2079294958 hasConceptScore W2079294958C2779438470 @default.
• W2079294958 hasConceptScore W2079294958C2780580887 @default.
• W2079294958 hasConceptScore W2079294958C2781182431 @default.
• W2079294958 hasConceptScore W2079294958C36823959 @default.
• W2079294958 hasConceptScore W2079294958C42362537 @default.
• W2079294958 hasConceptScore W2079294958C49105822 @default.
• W2079294958 hasConceptScore W2079294958C501734568 @default.

• next