Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079298086> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2079298086 abstract "Malaria is the third most prevalent cause of infectious disease in the world. Resistance of the parasite to classical drugs makes the discovery of new and effective drugs more urgent. The oxidized derivative of hydroxy-cis terpenone (OHCT) is a synthetic molecule that is not toxic to cultured human liver cells at concentrations as high as 60 microM and inhibits activity of cytochrome P450s that metabolize many drugs.OHCT activity against chloroquine-sensitive and -resistant strains of Plasmodium falciparum, and a P. falciparum clone that is partially resistant to artemisinin was assayed in vitro.OHCT at nanomolar concentrations was effective against all intraerythrocytic stages of P. falciparum and exhibited activity in vitro against both chloroquine-sensitive and -resistant strains of P. falciparum as well as a P. falciparum clone that is partially resistant to artemisinin. Moreover, OHCT exhibited potent activity against gametocytes, the form that is transmitted by mosquitoes and essential for the spread of malaria.OHCT displays strong growth inhibitory activity against all stages of P. falciparum and no evidence of toxicity to human cells in culture. It is easily synthesized and has the potential for inhibiting metabolism of drugs used in combination therapies." @default.
- W2079298086 created "2016-06-24" @default.
- W2079298086 creator A5031134327 @default.
- W2079298086 creator A5056158779 @default.
- W2079298086 creator A5079322514 @default.
- W2079298086 creator A5081274619 @default.
- W2079298086 creator A5087835694 @default.
- W2079298086 date "2009-06-25" @default.
- W2079298086 modified "2023-10-15" @default.
- W2079298086 title "Antimalarial activity of a cis-terpenone" @default.
- W2079298086 cites W1692234463 @default.
- W2079298086 cites W1969503178 @default.
- W2079298086 cites W1985779452 @default.
- W2079298086 cites W2013666488 @default.
- W2079298086 cites W2025698425 @default.
- W2079298086 cites W2041422568 @default.
- W2079298086 cites W2043105877 @default.
- W2079298086 cites W2043778000 @default.
- W2079298086 cites W2053851061 @default.
- W2079298086 cites W2054525174 @default.
- W2079298086 cites W2063351083 @default.
- W2079298086 cites W2064110684 @default.
- W2079298086 cites W2073911537 @default.
- W2079298086 cites W2091958115 @default.
- W2079298086 cites W2187295707 @default.
- W2079298086 cites W2415984255 @default.
- W2079298086 doi "https://doi.org/10.1186/1475-2875-8-139" @default.
- W2079298086 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2711970" @default.
- W2079298086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19555505" @default.
- W2079298086 hasPublicationYear "2009" @default.
- W2079298086 type Work @default.
- W2079298086 sameAs 2079298086 @default.
- W2079298086 citedByCount "4" @default.
- W2079298086 countsByYear W20792980862012 @default.
- W2079298086 countsByYear W20792980862014 @default.
- W2079298086 countsByYear W20792980862015 @default.
- W2079298086 crossrefType "journal-article" @default.
- W2079298086 hasAuthorship W2079298086A5031134327 @default.
- W2079298086 hasAuthorship W2079298086A5056158779 @default.
- W2079298086 hasAuthorship W2079298086A5079322514 @default.
- W2079298086 hasAuthorship W2079298086A5081274619 @default.
- W2079298086 hasAuthorship W2079298086A5087835694 @default.
- W2079298086 hasBestOaLocation W20792980861 @default.
- W2079298086 hasConcept C114851261 @default.
- W2079298086 hasConcept C159047783 @default.
- W2079298086 hasConcept C190612196 @default.
- W2079298086 hasConcept C202751555 @default.
- W2079298086 hasConcept C203014093 @default.
- W2079298086 hasConcept C2776120307 @default.
- W2079298086 hasConcept C2777425658 @default.
- W2079298086 hasConcept C2778048844 @default.
- W2079298086 hasConcept C2778371730 @default.
- W2079298086 hasConcept C55493867 @default.
- W2079298086 hasConcept C86803240 @default.
- W2079298086 hasConcept C89423630 @default.
- W2079298086 hasConcept C90856448 @default.
- W2079298086 hasConcept C98274493 @default.
- W2079298086 hasConcept C99389464 @default.
- W2079298086 hasConceptScore W2079298086C114851261 @default.
- W2079298086 hasConceptScore W2079298086C159047783 @default.
- W2079298086 hasConceptScore W2079298086C190612196 @default.
- W2079298086 hasConceptScore W2079298086C202751555 @default.
- W2079298086 hasConceptScore W2079298086C203014093 @default.
- W2079298086 hasConceptScore W2079298086C2776120307 @default.
- W2079298086 hasConceptScore W2079298086C2777425658 @default.
- W2079298086 hasConceptScore W2079298086C2778048844 @default.
- W2079298086 hasConceptScore W2079298086C2778371730 @default.
- W2079298086 hasConceptScore W2079298086C55493867 @default.
- W2079298086 hasConceptScore W2079298086C86803240 @default.
- W2079298086 hasConceptScore W2079298086C89423630 @default.
- W2079298086 hasConceptScore W2079298086C90856448 @default.
- W2079298086 hasConceptScore W2079298086C98274493 @default.
- W2079298086 hasConceptScore W2079298086C99389464 @default.
- W2079298086 hasIssue "1" @default.
- W2079298086 hasLocation W20792980861 @default.
- W2079298086 hasLocation W20792980862 @default.
- W2079298086 hasLocation W20792980863 @default.
- W2079298086 hasLocation W20792980864 @default.
- W2079298086 hasLocation W20792980865 @default.
- W2079298086 hasLocation W20792980866 @default.
- W2079298086 hasOpenAccess W2079298086 @default.
- W2079298086 hasPrimaryLocation W20792980861 @default.
- W2079298086 hasRelatedWork W2035165904 @default.
- W2079298086 hasRelatedWork W2092661478 @default.
- W2079298086 hasRelatedWork W2145094277 @default.
- W2079298086 hasRelatedWork W2163250777 @default.
- W2079298086 hasRelatedWork W2164650854 @default.
- W2079298086 hasRelatedWork W2257185490 @default.
- W2079298086 hasRelatedWork W2939963647 @default.
- W2079298086 hasRelatedWork W2944421948 @default.
- W2079298086 hasRelatedWork W2968900149 @default.
- W2079298086 hasRelatedWork W4211150857 @default.
- W2079298086 hasVolume "8" @default.
- W2079298086 isParatext "false" @default.
- W2079298086 isRetracted "false" @default.
- W2079298086 magId "2079298086" @default.
- W2079298086 workType "article" @default.