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• W2079298468 startingPage "773" @default.
• W2079298468 abstract "Anaphylactic shock was induced with ovalbumin in sensitized rats and the relationship between PGE 2 and cyclic nucleotides in lung tissue and plasma histamine during anaphylactic shock was studied. PGE 2 level and cyclic AMP/cyclic GMP ratio decreased with this ovalbumin-challenge, and the former reached a minimum value 40 sec after the challenge while the latter reached a minimum value 20 sec later. The plasma histamine level was elevated and reached a maximum value concomitant with the minimum value in the cyclic AMP/cyclic GMP ratio. Dibutyryl cyclic AMP elevated the PGE 2 level significantly and inhibited the ovalbumin-induced elevation of plasma histamine, however, this effect was abolished by the administration of indomethacin. PGE 2 infusion elevated the cyclic AMP level as well as the cyclic AMP/cyclic GMP ratio, in a time-dependent manner, and inhibited the oval burnin-induced elevation of plasma histamine during 10 min infusion. There was a significant correlation between the cyclic AMP level and the cyclic AMP/cyclic GMP ratio, both elevated by PGE 2 infusion. Thus, anaphylactic elevation of the plasma histamine level results from a decrease in the levels of PGE 2 in lung tissue rather than a decrease in the cyclic AMP/cyclic GMP ratio, albeit these decreases being coincident during anaphylactic shock." @default.
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• W2079298468 date "1980-01-01" @default.
• W2079298468 modified "2023-09-27" @default.
• W2079298468 title "Prostaglandin E2 and cyclic nucleotides during anaphylactic shock in rats." @default.
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• W2079298468 doi "https://doi.org/10.1254/jjp.30.773" @default.
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