FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079301619> ?p ?o ?g. }

• W2079301619 endingPage "494" @default.
• W2079301619 startingPage "481" @default.
• W2079301619 abstract "Members of the signal transducer and activator of transcription (STAT) family of transcription factors are potential targets for the treatment and prevention of cancers including non-small-cell lung cancer. STAT proteins can be phosphorylated and activated by diverse upstream kinases including cytokine receptors and tyrosine kinases. We examined STAT protein activation in lung cancer cell lines including those with activating mutations in the EGFR and examined upstream kinases responsible for STAT3 phosphorylation and activation using small molecules, antibodies, and RNA interference. We found more pronounced STAT3 activation in cells with activating EGFR mutations, yet inhibition of EGFR activity had no effect on STAT3 activation. Inhibition of JAK1 with small molecules or RNA interference resulted in loss of STAT3 tyrosine phosphorylation and inhibition of cell growth. An interleukin-6 neutralizing antibody, siltuximab (CNTO 328) could inhibit STAT3 tyrosine phosphorylation in a cell-dependent manner. Siltuximab could completely inhibit STAT3 tyrosine phosphorylation in H1650 cells, and this resulted in inhibition of lung cancer cell growth in vivo. Combined EGFR inhibition with erlotinib and siltuximab resulted in dual inhibition of both tyrosine and serine STAT3 phosphorylation, more pronounced inhibition of STAT3 transcriptional activity, and translated into combined effects on lung cancer growth in a mouse model. Our results suggest that JAK1 is responsible for STAT3 activation in lung cancer cells and that indirect attacks on JAK1-STAT3 using an IL-6 neutralizing antibody with or without EGFR inhibition can inhibit lung cancer growth in lung cancer subsets." @default.
• W2079301619 created "2016-06-24" @default.
• W2079301619 creator A5013240234 @default.
• W2079301619 creator A5014499906 @default.
• W2079301619 creator A5064494204 @default.
• W2079301619 creator A5067347913 @default.
• W2079301619 date "2011-03-01" @default.
• W2079301619 modified "2023-10-14" @default.
• W2079301619 title "JAK1 Activates STAT3 Activity in Non-Small–Cell Lung Cancer Cells and IL-6 Neutralizing Antibodies Can Suppress JAK1-STAT3 Signaling" @default.
• W2079301619 cites W1548640328 @default.
• W2079301619 cites W1779691448 @default.
• W2079301619 cites W1968855063 @default.
• W2079301619 cites W1977690036 @default.
• W2079301619 cites W1982585264 @default.
• W2079301619 cites W1994479081 @default.
• W2079301619 cites W1996516526 @default.
• W2079301619 cites W1996954880 @default.
• W2079301619 cites W2000707284 @default.
• W2079301619 cites W2001888458 @default.
• W2079301619 cites W2017715430 @default.
• W2079301619 cites W2020995084 @default.
• W2079301619 cites W2022200777 @default.
• W2079301619 cites W2026318599 @default.
• W2079301619 cites W2029813057 @default.
• W2079301619 cites W2030865745 @default.
• W2079301619 cites W2032775411 @default.
• W2079301619 cites W2036223010 @default.
• W2079301619 cites W2037873277 @default.
• W2079301619 cites W2043103956 @default.
• W2079301619 cites W2052276044 @default.
• W2079301619 cites W2064117666 @default.
• W2079301619 cites W2071437006 @default.
• W2079301619 cites W2086307485 @default.
• W2079301619 cites W2098455835 @default.
• W2079301619 cites W2099805317 @default.
• W2079301619 cites W2107631090 @default.
• W2079301619 cites W2114464348 @default.
• W2079301619 cites W2120181506 @default.
• W2079301619 cites W2131152510 @default.
• W2079301619 cites W2133729896 @default.
• W2079301619 cites W2137158350 @default.
• W2079301619 cites W2152532651 @default.
• W2079301619 doi "https://doi.org/10.1158/1535-7163.mct-10-0502" @default.
• W2079301619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4084653" @default.
• W2079301619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21216930" @default.
• W2079301619 hasPublicationYear "2011" @default.
• W2079301619 type Work @default.
• W2079301619 sameAs 2079301619 @default.
• W2079301619 citedByCount "144" @default.
• W2079301619 countsByYear W20793016192012 @default.
• W2079301619 countsByYear W20793016192013 @default.
• W2079301619 countsByYear W20793016192014 @default.
• W2079301619 countsByYear W20793016192015 @default.
• W2079301619 countsByYear W20793016192016 @default.
• W2079301619 countsByYear W20793016192017 @default.
• W2079301619 countsByYear W20793016192018 @default.
• W2079301619 countsByYear W20793016192019 @default.
• W2079301619 countsByYear W20793016192020 @default.
• W2079301619 countsByYear W20793016192021 @default.
• W2079301619 countsByYear W20793016192022 @default.
• W2079301619 countsByYear W20793016192023 @default.
• W2079301619 crossrefType "journal-article" @default.
• W2079301619 hasAuthorship W2079301619A5013240234 @default.
• W2079301619 hasAuthorship W2079301619A5014499906 @default.
• W2079301619 hasAuthorship W2079301619A5064494204 @default.
• W2079301619 hasAuthorship W2079301619A5067347913 @default.
• W2079301619 hasBestOaLocation W20793016191 @default.
• W2079301619 hasConcept C11960822 @default.
• W2079301619 hasConcept C153911025 @default.
• W2079301619 hasConcept C171958077 @default.
• W2079301619 hasConcept C184235292 @default.
• W2079301619 hasConcept C185592680 @default.
• W2079301619 hasConcept C2777553839 @default.
• W2079301619 hasConcept C2778923194 @default.
• W2079301619 hasConcept C2779707156 @default.
• W2079301619 hasConcept C42362537 @default.
• W2079301619 hasConcept C502942594 @default.
• W2079301619 hasConcept C55493867 @default.
• W2079301619 hasConcept C62112901 @default.
• W2079301619 hasConcept C62478195 @default.
• W2079301619 hasConcept C86803240 @default.
• W2079301619 hasConcept C95444343 @default.
• W2079301619 hasConceptScore W2079301619C11960822 @default.
• W2079301619 hasConceptScore W2079301619C153911025 @default.
• W2079301619 hasConceptScore W2079301619C171958077 @default.
• W2079301619 hasConceptScore W2079301619C184235292 @default.
• W2079301619 hasConceptScore W2079301619C185592680 @default.
• W2079301619 hasConceptScore W2079301619C2777553839 @default.
• W2079301619 hasConceptScore W2079301619C2778923194 @default.
• W2079301619 hasConceptScore W2079301619C2779707156 @default.
• W2079301619 hasConceptScore W2079301619C42362537 @default.
• W2079301619 hasConceptScore W2079301619C502942594 @default.
• W2079301619 hasConceptScore W2079301619C55493867 @default.
• W2079301619 hasConceptScore W2079301619C62112901 @default.
• W2079301619 hasConceptScore W2079301619C62478195 @default.
• W2079301619 hasConceptScore W2079301619C86803240 @default.
• W2079301619 hasConceptScore W2079301619C95444343 @default.
• W2079301619 hasIssue "3" @default.

• next