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• W2079301867 abstract "Protein-coding genes in eukaryotes are interrupted by introns, but intron densities widely differ between eukaryotic lineages. Vertebrates, some invertebrates and green plants have intron-rich genes, with 6-7 introns per kilobase of coding sequence, whereas most of the other eukaryotes have intron-poor genes. We reconstructed the history of intron gain and loss using a probabilistic Markov model (Markov Chain Monte Carlo, MCMC) on 245 orthologous genes from 99 genomes representing the three of the five supergroups of eukaryotes for which multiple genome sequences are available. Intron-rich ancestors are confidently reconstructed for each major group, with 53 to 74% of the human intron density inferred with 95% confidence for the Last Eukaryotic Common Ancestor (LECA). The results of the MCMC reconstruction are compared with the reconstructions obtained using Maximum Likelihood (ML) and Dollo parsimony methods. An excellent agreement between the MCMC and ML inferences is demonstrated whereas Dollo parsimony introduces a noticeable bias in the estimations, typically yielding lower ancestral intron densities than MCMC and ML. Evolution of eukaryotic genes was dominated by intron loss, with substantial gain only at the bases of several major branches including plants and animals. The highest intron density, 120 to 130% of the human value, is inferred for the last common ancestor of animals. The reconstruction shows that the entire line of descent from LECA to mammals was intron-rich, a state conducive to the evolution of alternative splicing." @default.
• W2079301867 created "2016-06-24" @default.
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• W2079301867 date "2011-09-01" @default.
• W2079301867 modified "2023-10-17" @default.
• W2079301867 title "A detailed history of intron-rich eukaryotic ancestors inferred from a global survey of 100 complete genomes." @default.
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• W2079301867 doi "https://doi.org/10.1371/journal.pcbi.1002150" @default.
• W2079301867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3174169" @default.
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• W2079301867 hasPublicationYear "2011" @default.
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