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• W2079302529 endingPage "1344" @default.
• W2079302529 startingPage "1323" @default.
• W2079302529 abstract "Septin hetero-oligomers polymerize into cytoskeletal filaments with essential functions in many eukaryotic cell types. Mutations within the oligomerization interface that encompasses the GTP-binding pocket of a septin (its “G interface”) cause thermoinstability of yeast septin hetero-oligomer assembly, and human disease. When coexpressed with its wild-type counterpart, a G interface mutant is excluded from septin filaments, even at moderate temperatures. We show that this quality control mechanism is specific to G interface mutants, operates during de novo septin hetero-oligomer assembly, and requires specific cytosolic chaperones. Chaperone overexpression lowers the temperature permissive for proliferation of cells expressing a G interface mutant as the sole source of a given septin. Mutations that perturb the septin G interface retard release from these chaperones, imposing a kinetic delay on the availability of nascent septin molecules for higher-order assembly. Un­expectedly, the disaggregase Hsp104 contributes to this delay in a manner that does not require its “unfoldase” activity, indicating a latent “holdase” activity toward mutant septins. These findings provide new roles for chaperone-mediated kinetic partitioning of non-native proteins and may help explain the etiology of septin-linked human diseases." @default.
• W2079302529 created "2016-06-24" @default.
• W2079302529 creator A5018473659 @default.
• W2079302529 creator A5048920959 @default.
• W2079302529 creator A5059374123 @default.
• W2079302529 creator A5069819026 @default.
• W2079302529 creator A5078040703 @default.
• W2079302529 date "2015-04-01" @default.
• W2079302529 modified "2023-09-28" @default.
• W2079302529 title "Cytosolic chaperones mediate quality control of higher-order septin assembly in budding yeast" @default.
• W2079302529 cites W1481342470 @default.
• W2079302529 cites W1482772159 @default.
• W2079302529 cites W1482871107 @default.
• W2079302529 cites W1498543655 @default.
• W2079302529 cites W1544760453 @default.
• W2079302529 cites W1597352920 @default.
• W2079302529 cites W1600028054 @default.
• W2079302529 cites W1784052398 @default.
• W2079302529 cites W1960146171 @default.
• W2079302529 cites W1965649202 @default.
• W2079302529 cites W1967908056 @default.
• W2079302529 cites W1969296635 @default.
• W2079302529 cites W1970270735 @default.
• W2079302529 cites W1970717957 @default.
• W2079302529 cites W1983588814 @default.
• W2079302529 cites W1986188355 @default.
• W2079302529 cites W1987336694 @default.
• W2079302529 cites W1987623678 @default.
• W2079302529 cites W1994345832 @default.
• W2079302529 cites W1996645786 @default.
• W2079302529 cites W1998076098 @default.
• W2079302529 cites W1999687545 @default.
• W2079302529 cites W2004180261 @default.
• W2079302529 cites W2008200554 @default.
• W2079302529 cites W2009051079 @default.
• W2079302529 cites W2011368229 @default.
• W2079302529 cites W2011468419 @default.
• W2079302529 cites W2013112316 @default.
• W2079302529 cites W2015040639 @default.
• W2079302529 cites W2020017362 @default.
• W2079302529 cites W2024384866 @default.
• W2079302529 cites W2025709302 @default.
• W2079302529 cites W2029445443 @default.
• W2079302529 cites W2035091329 @default.
• W2079302529 cites W2037747220 @default.
• W2079302529 cites W2039639602 @default.
• W2079302529 cites W2041474954 @default.
• W2079302529 cites W2044248178 @default.
• W2079302529 cites W2044649127 @default.
• W2079302529 cites W2046477340 @default.
• W2079302529 cites W2048929757 @default.
• W2079302529 cites W2057764157 @default.
• W2079302529 cites W2059277971 @default.
• W2079302529 cites W2059493348 @default.
• W2079302529 cites W2071466766 @default.
• W2079302529 cites W2075302437 @default.
• W2079302529 cites W2075993250 @default.
• W2079302529 cites W2078116784 @default.
• W2079302529 cites W2079173253 @default.
• W2079302529 cites W2084626189 @default.
• W2079302529 cites W2087117016 @default.
• W2079302529 cites W2088190945 @default.
• W2079302529 cites W2089368424 @default.
• W2079302529 cites W2092476071 @default.
• W2079302529 cites W2092986760 @default.
• W2079302529 cites W2099234264 @default.
• W2079302529 cites W2099440216 @default.
• W2079302529 cites W2100169899 @default.
• W2079302529 cites W2103453943 @default.
• W2079302529 cites W2103758312 @default.
• W2079302529 cites W2103885056 @default.
• W2079302529 cites W2105695521 @default.
• W2079302529 cites W2108148669 @default.
• W2079302529 cites W2109102812 @default.
• W2079302529 cites W2115393465 @default.
• W2079302529 cites W2115429230 @default.
• W2079302529 cites W2118843271 @default.
• W2079302529 cites W2120129786 @default.
• W2079302529 cites W2122142406 @default.
• W2079302529 cites W2127390714 @default.
• W2079302529 cites W2127422455 @default.
• W2079302529 cites W2127839763 @default.
• W2079302529 cites W2133102806 @default.
• W2079302529 cites W2135717063 @default.
• W2079302529 cites W2136572619 @default.
• W2079302529 cites W2138118208 @default.
• W2079302529 cites W2138309685 @default.
• W2079302529 cites W2140197221 @default.
• W2079302529 cites W2140518858 @default.
• W2079302529 cites W2145922063 @default.
• W2079302529 cites W2146200179 @default.
• W2079302529 cites W2146632337 @default.
• W2079302529 cites W2147143173 @default.
• W2079302529 cites W2147984622 @default.
• W2079302529 cites W2152625922 @default.
• W2079302529 cites W2153574614 @default.
• W2079302529 cites W2154880168 @default.
• W2079302529 cites W2155194854 @default.

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