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- W2079302936 abstract "A generation ago, a melding of imagination and experimental evidence led to the hypothesis that catecholamines were essential in establishing basal cardiac pacemaking rhythm. Subsequent discoveries of depolarizing pacemaker currents and viable adult catecholamine-deficient animals raised serious doubts about the necessity of catecholamines in pacemaking. However, the findings that catecholamines are produced in pacemaking regions prior to innervation, and that they are required for embryonic survival during a defined critical period of embryonic development have revitalized the original hypothesis. Recent results have further suggested that intrinsic cardiac adrenergic cells can differentiate into pacemaking myocytes, and that protein kinase A, a prominent downstream mediator of beta-adrenergic signaling, is required for pacemaking activity. Here, we discuss how catecholamines and the intrinsic cardiac adrenergic cells that produce them may influence ontological development of cardiac pacemaking." @default.
- W2079302936 created "2016-06-24" @default.
- W2079302936 creator A5012590888 @default.
- W2079302936 creator A5026691427 @default.
- W2079302936 date "2006-12-01" @default.
- W2079302936 modified "2023-09-27" @default.
- W2079302936 title "Catecholamines and development of cardiac pacemaking: An intrinsically intimate relationship" @default.
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- W2079302936 doi "https://doi.org/10.1016/j.cardiores.2006.08.013" @default.
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