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- W2079307975 abstract "Three analogs of mycobactin T, the siderophore secreted by Mycobacterium tuberculosis (Mtb) were synthesized and screened for their antibiotic activity against Mtb H(37)Rv and a broad panel of Gram-positive and Gram-negative bacteria. The synthetic mycobactins were potent (MIC(90) 0.02-0.88 μM in 7H12 media) and selective Mtb inhibitors, with no inhibitory activity observed against any other of the microorganisms tested. The maleimide-containing analog 40 represents a versatile platform for the development of mycobactin-drug conjugates, as well as other applications." @default.
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- W2079307975 date "2012-01-01" @default.
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- W2079307975 title "Syntheses of mycobactin analogs as potent and selective inhibitors of Mycobacterium tuberculosis" @default.
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- W2079307975 doi "https://doi.org/10.1039/c2ob26077h" @default.
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