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- W2079308004 abstract "Expression of key regulatory enzymes involved in glucose metabolism was studied in the livers of Otsuka Long-Evans Tokushima fatty (OLETF) rats, a model of non-insulin dependent diabetes mellitus. The activity and mRNA levels of glucokinase and L-type pyruvate kinase was increased in the liver of OLETF rats compared with control rats. There was no such remarkable change in liver-type phosphofructokinase. The activities of glucose-6-phosphatase and fructose-1,6-biphosphatase also increase despite high plasma levels of glucose and insulin. The activity of phosphoenolpyruvate carboxykinase did not show any significant change. The mRNA levels for fructose-1,6-biphosphatase, and phosphoenolpyruvate carboxykinase exhibited no marked changes. These results suggest that the expression of glucose-6-phosphatase and fructose-1,6-biphosphatase is disordered in OLETF rats." @default.
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- W2079308004 date "1996-02-01" @default.
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- W2079308004 title "Disordered expression of hepatic glycolytic and gluconeogenic enzymes in Itsuka long-evans Tokushima fatty rats with spontaneous long-term hyperglycemia" @default.
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- W2079308004 doi "https://doi.org/10.1016/0304-4165(95)00148-4" @default.
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