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- W2079312761 endingPage "357" @default.
- W2079312761 startingPage "345" @default.
- W2079312761 abstract "In spite of significant advances in treatment of patients with schizophrenia and continued efforts towards their deinstitutionalization, a considerable group of patients remain chronically hospitalized or otherwise dependent on others for basic necessities of life. It has been proposed that these patients belong to a distinct etiopathological subgroup, termed Kraepelinian, whose course of illness may be progressive and resistant to treatment. Indeed, longitudinal studies appear to show that elderly Kraepelinian patients follow a course of rapid cognitive and functional deterioration, commensurate with a dementing process, and that their poor functional status is closely correlated with the cognitive deterioration. Recent neuroimaging studies described a pattern of posteriorization of grey and white matter deficits with poor outcome in schizophrenia, and produced a constellation of findings implicating primary processing of visual and auditory information as central to the impaired functional status in this patient group. These studies are summarized in detail in this review and future directions for neuroimaging assessment of very poor outcome patients with schizophrenia are suggested." @default.
- W2079312761 created "2016-06-24" @default.
- W2079312761 creator A5003010692 @default.
- W2079312761 creator A5080557011 @default.
- W2079312761 date "2007-01-01" @default.
- W2079312761 modified "2023-09-27" @default.
- W2079312761 title "Very poor outcome schizophrenia: Clinical and neuroimaging aspects" @default.
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