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• W2079314404 abstract "Interleukin-7 (IL-7) promotes the maintenance and activation of peripheral T cells, whereas it does not act directly on mature B cells due to the lack of IL-7Rα expression on these. We report here that, in spite of the insensitivity of B cells to IL-7, high concentration of IL-7 can lead to increased B cell survival and antibody production in the presence of T cells, without the use of any further B cell stimulatory signal. IL-7 promoted B cell activation through inducing CD70 expression on resting T cells, particularly on CD4+ memory cells. The interaction of CD70 molecules with the B cell costimulatory receptor CD27 led to B cell proliferation, the accumulation of CD38 + CD20- plasmablasts and antibody production. In addition, IL-7 treatment induced BAFF secretion from resting peripheral T cells thereby promoting B cell survival. IL-7 levels can increase in lymphopenic conditions, in autoimmune diseases or in patients receiving T cell regenerative IL-7 therapy. Based on our findings high IL-7 levels can lead to increased B cell activation by inducing the B cell regulatory proteins CD70 and BAFF in resting T cells. Such activity might be beneficial in short term immune-stimulatory IL-7 therapies; permanently increased IL-7 levels, on the other hand, can contribute to impaired B cell tolerance." @default.
• W2079314404 created "2016-06-24" @default.
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• W2079314404 date "2012-06-01" @default.
• W2079314404 modified "2023-09-25" @default.
• W2079314404 title "IL-7 modulates B cells survival and activation by inducing BAFF and CD70 expression in T cells" @default.
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• W2079314404 doi "https://doi.org/10.1016/j.jaut.2012.01.012" @default.
• W2079314404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22341853" @default.
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