Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079321364> ?p ?o ?g. }
- W2079321364 endingPage "1186" @default.
- W2079321364 startingPage "1181" @default.
- W2079321364 abstract "The present study investigated the effect of a single bout of exhaustive exercise on the generation of DNA strand breaks and oxidative DNA damage under normal conditions and at high-altitude hypoxia (4559 meters for 3 days). Twelve healthy subjects performed a maximal bicycle exercise test; lymphocytes were isolated for analysis of DNA strand breaks and oxidatively altered nucleotides, detected by endonuclease III and formamidipyridine glycosylase (FPG) enzymes. Urine was collected for 24 h periods for analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG), a marker of oxidative DNA damage. Urinary excretion of 8-oxodG increased during the first day in altitude hypoxia, and there were more endonuclease III-sensitive sites on day 3 at high altitude. The subjects had more DNA strand breaks in altitude hypoxia than at sea level. The level of DNA strand breaks further increased immediately after exercise in altitude hypoxia. Exercise-induced generation of DNA strand breaks was not seen at sea level. In both environments, the level of FPG and endonuclease III-sensitive sites remained unchanged immediately after exercise. DNA strand breaks and oxidative DNA damage are probably produced by reactive oxygen species, generated by leakage of the mitochondrial respiration or during a hypoxia-induced inflammation. Furthermore, the presence of DNA strand breaks may play an important role in maintaining hypoxia-induced inflammation processes. Hypoxia seems to deplete the antioxidant system of its capacity to withstand oxidative stress produced by exhaustive exercise." @default.
- W2079321364 created "2016-06-24" @default.
- W2079321364 creator A5021170936 @default.
- W2079321364 creator A5021762389 @default.
- W2079321364 creator A5034937943 @default.
- W2079321364 creator A5066850019 @default.
- W2079321364 date "2001-05-01" @default.
- W2079321364 modified "2023-10-16" @default.
- W2079321364 title "Acute hypoxia and hypoxic exercise induce DNA strand breaks and oxidative DNA damage in humans" @default.
- W2079321364 cites W106742883 @default.
- W2079321364 cites W1514869730 @default.
- W2079321364 cites W1546511498 @default.
- W2079321364 cites W1774496769 @default.
- W2079321364 cites W1908705450 @default.
- W2079321364 cites W1919901402 @default.
- W2079321364 cites W1960095976 @default.
- W2079321364 cites W1969224837 @default.
- W2079321364 cites W1987447695 @default.
- W2079321364 cites W1991114625 @default.
- W2079321364 cites W1999509419 @default.
- W2079321364 cites W2004683841 @default.
- W2079321364 cites W2007462786 @default.
- W2079321364 cites W2010969329 @default.
- W2079321364 cites W2016586685 @default.
- W2079321364 cites W2022303639 @default.
- W2079321364 cites W2022958403 @default.
- W2079321364 cites W2030364725 @default.
- W2079321364 cites W2030820195 @default.
- W2079321364 cites W2039207179 @default.
- W2079321364 cites W2046196654 @default.
- W2079321364 cites W2051059335 @default.
- W2079321364 cites W2055003799 @default.
- W2079321364 cites W2055422299 @default.
- W2079321364 cites W2057778104 @default.
- W2079321364 cites W2061026040 @default.
- W2079321364 cites W2063295363 @default.
- W2079321364 cites W2063998682 @default.
- W2079321364 cites W2076203177 @default.
- W2079321364 cites W2080114296 @default.
- W2079321364 cites W2100469265 @default.
- W2079321364 cites W2116830391 @default.
- W2079321364 cites W2117880268 @default.
- W2079321364 cites W2127381835 @default.
- W2079321364 cites W2137148755 @default.
- W2079321364 cites W2144918294 @default.
- W2079321364 cites W2153792548 @default.
- W2079321364 cites W2160323607 @default.
- W2079321364 cites W2161877652 @default.
- W2079321364 cites W2166804883 @default.
- W2079321364 cites W2180038398 @default.
- W2079321364 doi "https://doi.org/10.1096/fj.00-0703com" @default.
- W2079321364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11344086" @default.
- W2079321364 hasPublicationYear "2001" @default.
- W2079321364 type Work @default.
- W2079321364 sameAs 2079321364 @default.
- W2079321364 citedByCount "219" @default.
- W2079321364 countsByYear W20793213642012 @default.
- W2079321364 countsByYear W20793213642013 @default.
- W2079321364 countsByYear W20793213642014 @default.
- W2079321364 countsByYear W20793213642015 @default.
- W2079321364 countsByYear W20793213642016 @default.
- W2079321364 countsByYear W20793213642017 @default.
- W2079321364 countsByYear W20793213642018 @default.
- W2079321364 countsByYear W20793213642019 @default.
- W2079321364 countsByYear W20793213642020 @default.
- W2079321364 countsByYear W20793213642021 @default.
- W2079321364 countsByYear W20793213642022 @default.
- W2079321364 countsByYear W20793213642023 @default.
- W2079321364 crossrefType "journal-article" @default.
- W2079321364 hasAuthorship W2079321364A5021170936 @default.
- W2079321364 hasAuthorship W2079321364A5021762389 @default.
- W2079321364 hasAuthorship W2079321364A5034937943 @default.
- W2079321364 hasAuthorship W2079321364A5066850019 @default.
- W2079321364 hasConcept C104317684 @default.
- W2079321364 hasConcept C143425029 @default.
- W2079321364 hasConcept C153911025 @default.
- W2079321364 hasConcept C178790620 @default.
- W2079321364 hasConcept C185592680 @default.
- W2079321364 hasConcept C24586158 @default.
- W2079321364 hasConcept C2776151105 @default.
- W2079321364 hasConcept C48349386 @default.
- W2079321364 hasConcept C540031477 @default.
- W2079321364 hasConcept C552990157 @default.
- W2079321364 hasConcept C55493867 @default.
- W2079321364 hasConcept C57600042 @default.
- W2079321364 hasConcept C7836513 @default.
- W2079321364 hasConcept C86803240 @default.
- W2079321364 hasConceptScore W2079321364C104317684 @default.
- W2079321364 hasConceptScore W2079321364C143425029 @default.
- W2079321364 hasConceptScore W2079321364C153911025 @default.
- W2079321364 hasConceptScore W2079321364C178790620 @default.
- W2079321364 hasConceptScore W2079321364C185592680 @default.
- W2079321364 hasConceptScore W2079321364C24586158 @default.
- W2079321364 hasConceptScore W2079321364C2776151105 @default.
- W2079321364 hasConceptScore W2079321364C48349386 @default.
- W2079321364 hasConceptScore W2079321364C540031477 @default.
- W2079321364 hasConceptScore W2079321364C552990157 @default.
- W2079321364 hasConceptScore W2079321364C55493867 @default.