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• W2079323334 abstract "As an extended study on development of anti-Alzheimer’s disease agent, we newly synthesized various dihydrofuran-fused perhydrophenanthrenes via o-quinodimethane chemistry. This study revealed that the introduction of carbon side-chain on 8-position or removal of the acetal moiety on 3-position arose a cytotoxicity on rat cortical neurons. On the other hand, the ethereal or thio-ethereal substituent on 8-position enhanced the elongation effect on Aβ-damaged neurons. The necessity of the cyano group on 10b position was also proved in this structure–activity-relationship study." @default.
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• W2079323334 date "2013-08-01" @default.
• W2079323334 modified "2023-10-14" @default.
• W2079323334 title "Structure–activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer’s disease agent" @default.
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• W2079323334 doi "https://doi.org/10.1016/j.bmc.2013.05.059" @default.
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