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- W2079334113 abstract "The effects of busulfan, in patients with myeloproliferative disorders (MPD) have been studied. The 35 patients examined had high platelet levels, chromosomal abnormalities and, in cases of polycythemia vera (PV) or essential thrombocythemia (ET), had retrovirus-like particles. Normal controls or patients with secondary thrombocytosis did not exhibit the chromosomal abnormalities or the virus-like particles. During busulfan therapy, a number of changes occurred; morphologically-intact viral particles were no longer evident under the electron microscope (EM); the reverse-transcriptase (RT)-like enzyme shifted from the 1.19 g/cm1 to the 1.25 g/cm3 density area in an equilibrium density gradient; and platelet ultrastructure underwent a dramatic transient, change then returned to normal. The change in enzyme density could be duplicated in vitro by stripping the membrane from the virus-like particle with non-ionic detergent. The morphological changes in the platelet included: a less dense cytoplasm; indistinct membranes; and a distended circular shape. These alterations give the impression of damage to the membrane and possibly the microtubular system. At the termination of treatment, platelet levels were back to normal (2–3 × 105/μl), virus indicators were no longer present and, as shown previously, chromosomal abnormalities also disappeared." @default.
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- W2079334113 title "Alteration of platelets and virus-like particles by busulfan in myeloproliferative disorders" @default.
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- W2079334113 doi "https://doi.org/10.1016/0145-2126(80)90050-8" @default.
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