FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079341009> ?p ?o ?g. }

• W2079341009 endingPage "3106" @default.
• W2079341009 startingPage "3102" @default.
• W2079341009 abstract "In our model of regulation, the observed lack of cooperativity in the binding of myosin subfragment 1 (S-1) with bound ATP to the troponin-tropomyosin-actin complex (regulated actin) is explained by S-1.ATP having about the same affinity for the conformation of the regulated actin that activates the myosin ATPase activity (turned-on form) and the conformation that does not activate the myosin ATPase activity (turned-off form). This predicts that, in the absence of Ca2+, S-1.ATP should not turn on the regulated actin filament. In the present study, we tested this prediction by using either unmodified S-1 or S-1 chemically modified with N,N'-p-phenylenedimaleimide (pPDM X S-1) so that functionally it acts like S-1.ATP, although it does not hydrolyze ATP. We found that, in the absence of Ca2+, neither S-1.ATP nor pPDM X S-1.ATP significantly turns on the ATPase activity of the regulated complex of actin and S-1 (acto X S-1). In contrast, in the presence of Ca2+, pPDM X S-1.ATP binding almost completely turns on the regulated acto.S-1 ATPase activity. These results can be explained by our original cooperativity model, with pPDM X S-1.ATP binding only approximately equal to 2-fold more strongly to the turned-on form than to the turned-off form of regulated actin. However, our results are not consistent with our alternative model, which predicts that if pPDM X S-1.ATP binds to actin in the absence of Ca2+ but does not turn on the ATPase activity, then it should also not turn on the ATPase activity in the presence of Ca2+." @default.
• W2079341009 created "2016-06-24" @default.
• W2079341009 creator A5004657382 @default.
• W2079341009 creator A5044235202 @default.
• W2079341009 creator A5066697360 @default.
• W2079341009 date "1987-05-01" @default.
• W2079341009 modified "2023-09-26" @default.
• W2079341009 title "Regulation of actomyosin ATPase activity by troponin-tropomyosin: effect of the binding of the myosin subfragment 1 (S-1).ATP complex." @default.
• W2079341009 cites W100430351 @default.
• W2079341009 cites W1480084192 @default.
• W2079341009 cites W1556587164 @default.
• W2079341009 cites W1560741647 @default.
• W2079341009 cites W1595817081 @default.
• W2079341009 cites W1620274191 @default.
• W2079341009 cites W1981983192 @default.
• W2079341009 cites W1989255509 @default.
• W2079341009 cites W2007288168 @default.
• W2079341009 cites W2015710581 @default.
• W2079341009 cites W2017854623 @default.
• W2079341009 cites W2033317179 @default.
• W2079341009 cites W2036271044 @default.
• W2079341009 cites W2043037632 @default.
• W2079341009 cites W2044692042 @default.
• W2079341009 cites W2048238144 @default.
• W2079341009 cites W2051165670 @default.
• W2079341009 cites W2076157048 @default.
• W2079341009 cites W2082754501 @default.
• W2079341009 cites W2083492593 @default.
• W2079341009 cites W2092187742 @default.
• W2079341009 cites W2105944799 @default.
• W2079341009 cites W2170249054 @default.
• W2079341009 cites W2178239314 @default.
• W2079341009 doi "https://doi.org/10.1073/pnas.84.10.3102" @default.
• W2079341009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/304816" @default.
• W2079341009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2953023" @default.
• W2079341009 hasPublicationYear "1987" @default.
• W2079341009 type Work @default.
• W2079341009 sameAs 2079341009 @default.
• W2079341009 citedByCount "35" @default.
• W2079341009 countsByYear W20793410092012 @default.
• W2079341009 countsByYear W20793410092019 @default.
• W2079341009 crossrefType "journal-article" @default.
• W2079341009 hasAuthorship W2079341009A5004657382 @default.
• W2079341009 hasAuthorship W2079341009A5044235202 @default.
• W2079341009 hasAuthorship W2079341009A5066697360 @default.
• W2079341009 hasBestOaLocation W20793410091 @default.
• W2079341009 hasConcept C107824862 @default.
• W2079341009 hasConcept C118552586 @default.
• W2079341009 hasConcept C12554922 @default.
• W2079341009 hasConcept C125705527 @default.
• W2079341009 hasConcept C141315368 @default.
• W2079341009 hasConcept C15744967 @default.
• W2079341009 hasConcept C15954220 @default.
• W2079341009 hasConcept C166014724 @default.
• W2079341009 hasConcept C181199279 @default.
• W2079341009 hasConcept C185592680 @default.
• W2079341009 hasConcept C187250156 @default.
• W2079341009 hasConcept C205875245 @default.
• W2079341009 hasConcept C23265538 @default.
• W2079341009 hasConcept C2779564974 @default.
• W2079341009 hasConcept C36036425 @default.
• W2079341009 hasConcept C500558357 @default.
• W2079341009 hasConcept C55493867 @default.
• W2079341009 hasConcept C6997183 @default.
• W2079341009 hasConcept C8035138 @default.
• W2079341009 hasConcept C86803240 @default.
• W2079341009 hasConceptScore W2079341009C107824862 @default.
• W2079341009 hasConceptScore W2079341009C118552586 @default.
• W2079341009 hasConceptScore W2079341009C12554922 @default.
• W2079341009 hasConceptScore W2079341009C125705527 @default.
• W2079341009 hasConceptScore W2079341009C141315368 @default.
• W2079341009 hasConceptScore W2079341009C15744967 @default.
• W2079341009 hasConceptScore W2079341009C15954220 @default.
• W2079341009 hasConceptScore W2079341009C166014724 @default.
• W2079341009 hasConceptScore W2079341009C181199279 @default.
• W2079341009 hasConceptScore W2079341009C185592680 @default.
• W2079341009 hasConceptScore W2079341009C187250156 @default.
• W2079341009 hasConceptScore W2079341009C205875245 @default.
• W2079341009 hasConceptScore W2079341009C23265538 @default.
• W2079341009 hasConceptScore W2079341009C2779564974 @default.
• W2079341009 hasConceptScore W2079341009C36036425 @default.
• W2079341009 hasConceptScore W2079341009C500558357 @default.
• W2079341009 hasConceptScore W2079341009C55493867 @default.
• W2079341009 hasConceptScore W2079341009C6997183 @default.
• W2079341009 hasConceptScore W2079341009C8035138 @default.
• W2079341009 hasConceptScore W2079341009C86803240 @default.
• W2079341009 hasIssue "10" @default.
• W2079341009 hasLocation W20793410091 @default.
• W2079341009 hasLocation W20793410092 @default.
• W2079341009 hasLocation W20793410093 @default.
• W2079341009 hasLocation W20793410094 @default.
• W2079341009 hasOpenAccess W2079341009 @default.
• W2079341009 hasPrimaryLocation W20793410091 @default.
• W2079341009 hasRelatedWork W1999301802 @default.
• W2079341009 hasRelatedWork W2011624620 @default.
• W2079341009 hasRelatedWork W2066585573 @default.
• W2079341009 hasRelatedWork W2074533205 @default.
• W2079341009 hasRelatedWork W2079341009 @default.

• next