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• W2079341775 abstract "Palmitoyl-CoA (Pal-CoA) lowered the respiratory control ratio (RCR), and induced mitochondrial membrane permeability transition (MPT) and cytochrome c (Cyt. c) release from isolated rat liver mitochondria. L-Carnitine suppressed the Pal-CoA-induced dysfunction, MPT, and Cyt. c release of isolated mitochondria. This suppression was inhibited by cephaloridine, an inhibitor of carnitine uptake into mitochondria. Cyclosporin A (CsA), an inhibitor of MPT, and BSA also suppressed the Pal-CoA-induced MPT. In the presence of inorganic phosphate (P(i)), Ca2+-induced MPT was suppressed by BSA, L-carnitine, and chlorpromazine, an inhibitor of phospholipase A2. In the presence of a low concentration of Ca2+, 3,3',5-triiodothyronine, long chain fatty acids, salicylic acid, and diclofenac induced MPT by a mechanism that was suppressed by BSA, L-carnitine, or chlorpromazine. During the incubation of mitochondria on ice, their respiratory competence decreased; L-carnitine and BSA also prevented this decrease. Mitochondrial depolarization in pheochromocytoma PC12 cells was induced by either serum deprivation or arachidonic acid by a mechanism that was suppressed by acetyl-L-carnitine. These results indicate that some MPTs may be regulated by fatty acid metabolism and that the Pal-CoA-induced MPT plays an important role in the induction of apoptosis." @default.
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• W2079341775 date "2001-11-01" @default.
• W2079341775 modified "2023-10-06" @default.
• W2079341775 title "Roles of long chain fatty acids and carnitine in mitochondrial membrane permeability transition11Abbreviations: CsA, cyclosporin A; Cyt. c, cytochrome c; FBS, fetal bovine serum; Pal-CoA, palmitoyl-CoA; Pi, inorganic phosphate; LCFA, long chain fatty acid; MPT, membrane permeability transition; PLA2, phospholipase A2; RCR, respiratory control ratio; and T3, 3,3′,5-triiodothyronine." @default.
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• W2079341775 doi "https://doi.org/10.1016/s0006-2952(01)00745-6" @default.
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