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- W2079342481 abstract "The extensive and sometimes irresponsible use of beta-lactam antibiotics in clinical and agricultural settings has contributed to the emergence and widespread dissemination of antibiotic-resistant bacteria. Bacteria have evolved three strategies to escape the activity of beta-lactam antibiotics: 1) alteration of the target site (e.g. penicillin-binding protein (PBPs), 2) reduction of drug permeation across the bacterial membrane (e.g. efflux pumps) and 3) production of beta-lactamase enzymes. The beta-lactamase enzymes inactivate beta-lactam antibiotics by hydrolyzing the peptide bond of the characteristic four-membered beta-lactam ring rendering the antibiotic ineffective. The inactivation of the antibiotic provides resistance to the bacterium. Currently, there are over 300 beta-lactamase enzymes described for which numerous kinetic, structural, computational and mutagenesis studies have been performed. In this review, we discuss the recent work performed on the four different classes (A, B, C, and D) of beta-lactamases. These investigative advances further expand our knowledge about these complex enzymes, and hopefully, will provide us with additional tools to develop new inhibitors and antibiotics based on structural and rational designs." @default.
- W2079342481 created "2016-06-24" @default.
- W2079342481 creator A5050982810 @default.
- W2079342481 creator A5051445651 @default.
- W2079342481 creator A5052440842 @default.
- W2079342481 date "2002-01-01" @default.
- W2079342481 modified "2023-10-14" @default.
- W2079342481 title "Molecular analysis of beta-lactamase structure and function" @default.
- W2079342481 cites W1491038242 @default.
- W2079342481 cites W1498996826 @default.
- W2079342481 cites W1528450034 @default.
- W2079342481 cites W1541568526 @default.
- W2079342481 cites W1649027544 @default.
- W2079342481 cites W1701997017 @default.
- W2079342481 cites W1718542199 @default.
- W2079342481 cites W1820365410 @default.
- W2079342481 cites W1870016320 @default.
- W2079342481 cites W1879027467 @default.
- W2079342481 cites W1907778005 @default.
- W2079342481 cites W1937785817 @default.
- W2079342481 cites W1965231274 @default.
- W2079342481 cites W1965518707 @default.
- W2079342481 cites W1965554873 @default.
- W2079342481 cites W1967061628 @default.
- W2079342481 cites W1967412894 @default.
- W2079342481 cites W1968471341 @default.
- W2079342481 cites W1968765650 @default.
- W2079342481 cites W1969181216 @default.
- W2079342481 cites W1969222445 @default.
- W2079342481 cites W1971137961 @default.
- W2079342481 cites W1975418104 @default.
- W2079342481 cites W1983522991 @default.
- W2079342481 cites W1985170646 @default.
- W2079342481 cites W1991870138 @default.
- W2079342481 cites W1996960109 @default.
- W2079342481 cites W2001608349 @default.
- W2079342481 cites W2003209171 @default.
- W2079342481 cites W2006639795 @default.
- W2079342481 cites W2010582645 @default.
- W2079342481 cites W2013021108 @default.
- W2079342481 cites W2018883772 @default.
- W2079342481 cites W2022174414 @default.
- W2079342481 cites W2022339017 @default.
- W2079342481 cites W2024657431 @default.
- W2079342481 cites W2025721958 @default.
- W2079342481 cites W2026130809 @default.
- W2079342481 cites W2031947878 @default.
- W2079342481 cites W2042588716 @default.
- W2079342481 cites W2045425212 @default.
- W2079342481 cites W2047709322 @default.
- W2079342481 cites W2050384005 @default.
- W2079342481 cites W2057958258 @default.
- W2079342481 cites W2065078821 @default.
- W2079342481 cites W2065668262 @default.
- W2079342481 cites W2066704242 @default.
- W2079342481 cites W2069644704 @default.
- W2079342481 cites W2074112877 @default.
- W2079342481 cites W2075328866 @default.
- W2079342481 cites W2076801181 @default.
- W2079342481 cites W2080267554 @default.
- W2079342481 cites W2083021997 @default.
- W2079342481 cites W2086186194 @default.
- W2079342481 cites W2088037578 @default.
- W2079342481 cites W2090654640 @default.
- W2079342481 cites W2093462397 @default.
- W2079342481 cites W2111516721 @default.
- W2079342481 cites W2113030266 @default.
- W2079342481 cites W2128577323 @default.
- W2079342481 cites W2131293087 @default.
- W2079342481 cites W2133676327 @default.
- W2079342481 cites W2134352676 @default.
- W2079342481 cites W2136033017 @default.
- W2079342481 cites W2136880793 @default.
- W2079342481 cites W2143874510 @default.
- W2079342481 cites W2147872249 @default.
- W2079342481 cites W2148609385 @default.
- W2079342481 cites W2159088328 @default.
- W2079342481 cites W2162478150 @default.
- W2079342481 cites W2163771433 @default.
- W2079342481 cites W2164667941 @default.
- W2079342481 cites W2167423771 @default.
- W2079342481 cites W2313929885 @default.
- W2079342481 cites W2338885120 @default.
- W2079342481 cites W31802177 @default.
- W2079342481 cites W4240436807 @default.
- W2079342481 doi "https://doi.org/10.1078/1438-4221-00198" @default.
- W2079342481 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12195735" @default.
- W2079342481 hasPublicationYear "2002" @default.
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