FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079343346> ?p ?o ?g. }

• W2079343346 endingPage "641" @default.
• W2079343346 startingPage "641" @default.
• W2079343346 abstract "Although neo-adjuvant radiotherapy is generally successful in treatment of advanced prostate cancer, radioresistance is still a major therapeutic problem in many patients. In the current study, we investigated the effects of metformin (1,1-dimethylbiguanide hydrochloride), a widely used antidiabetic drug, on tumor cell radiosensitivity in prostate cancer. Through clonogenic survival assays, we found that metformin treatment enhanced radiosensitivity of prostate cancer cells with a dose enhancement factor. Moreover, irradiation of subcutaneous C4-2 tumors in mice treated with metformin resulted in an increase in radiation-induced tumor growth delay (17.3 days to 29.5 days, P < 0.01), which indicates that the tumor radiosensitivity increased by metformin in vivo. We also measured the sublethal damage repair and analyzed double-strand breaks (DSBs) in X-irradiated cells. γ-H2AX, as an indicator of DSBs, had significantly more foci per cell in the group treated with metformin and radiation compared to groups treated with metformin or irradiation, respectively. Moreover, mice with subcutaneous tumor implants lived longer after a combined treatment of metformin and radiation. In addition, the reduced phosphorylation of DNA-PKcs caused by EGFR/PI3K/Akt down-regulation is essential for metformin to induce radiosensitivity in prostate cancer cells. Our results indicate that metformin enhances prostate cancer cell radiosensitivity in vitro and in vivo. Exposure to metformin before radiation therapy could be a beneficial option for the treatment of prostate cancer." @default.
• W2079343346 created "2016-06-24" @default.
• W2079343346 creator A5001451095 @default.
• W2079343346 creator A5013376200 @default.
• W2079343346 creator A5024833333 @default.
• W2079343346 creator A5028710085 @default.
• W2079343346 creator A5035701638 @default.
• W2079343346 creator A5038077662 @default.
• W2079343346 creator A5042008157 @default.
• W2079343346 creator A5048081746 @default.
• W2079343346 creator A5075889094 @default.
• W2079343346 creator A5085581217 @default.
• W2079343346 creator A5086783805 @default.
• W2079343346 date "2014-05-20" @default.
• W2079343346 modified "2023-10-17" @default.
• W2079343346 title "Metformin Sensitizes Prostate Cancer Cells to Radiation Through EGFR/p-DNA-PKCS In Vitro and In Vivo" @default.
• W2079343346 cites W145853903 @default.
• W2079343346 cites W1988173009 @default.
• W2079343346 cites W1988227131 @default.
• W2079343346 cites W1990063646 @default.
• W2079343346 cites W1997714593 @default.
• W2079343346 cites W1998771362 @default.
• W2079343346 cites W2005912218 @default.
• W2079343346 cites W2014134684 @default.
• W2079343346 cites W2025325600 @default.
• W2079343346 cites W2027557150 @default.
• W2079343346 cites W2034221484 @default.
• W2079343346 cites W2042008937 @default.
• W2079343346 cites W2057139536 @default.
• W2079343346 cites W2064656431 @default.
• W2079343346 cites W2073067473 @default.
• W2079343346 cites W2084969545 @default.
• W2079343346 cites W2100103895 @default.
• W2079343346 cites W2106381426 @default.
• W2079343346 cites W2107112594 @default.
• W2079343346 cites W2108058238 @default.
• W2079343346 cites W2108183713 @default.
• W2079343346 cites W2112129195 @default.
• W2079343346 cites W2115266735 @default.
• W2079343346 cites W2115325946 @default.
• W2079343346 cites W2118113452 @default.
• W2079343346 cites W2142007209 @default.
• W2079343346 cites W2143629217 @default.
• W2079343346 cites W2147589302 @default.
• W2079343346 cites W2153980878 @default.
• W2079343346 cites W2166583179 @default.
• W2079343346 cites W2166935017 @default.
• W2079343346 cites W4299575400 @default.
• W2079343346 doi "https://doi.org/10.1667/rr13561.1" @default.
• W2079343346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24844651" @default.
• W2079343346 hasPublicationYear "2014" @default.
• W2079343346 type Work @default.
• W2079343346 sameAs 2079343346 @default.
• W2079343346 citedByCount "39" @default.
• W2079343346 countsByYear W20793433462014 @default.
• W2079343346 countsByYear W20793433462015 @default.
• W2079343346 countsByYear W20793433462016 @default.
• W2079343346 countsByYear W20793433462017 @default.
• W2079343346 countsByYear W20793433462018 @default.
• W2079343346 countsByYear W20793433462019 @default.
• W2079343346 countsByYear W20793433462020 @default.
• W2079343346 countsByYear W20793433462021 @default.
• W2079343346 countsByYear W20793433462022 @default.
• W2079343346 countsByYear W20793433462023 @default.
• W2079343346 crossrefType "journal-article" @default.
• W2079343346 hasAuthorship W2079343346A5001451095 @default.
• W2079343346 hasAuthorship W2079343346A5013376200 @default.
• W2079343346 hasAuthorship W2079343346A5024833333 @default.
• W2079343346 hasAuthorship W2079343346A5028710085 @default.
• W2079343346 hasAuthorship W2079343346A5035701638 @default.
• W2079343346 hasAuthorship W2079343346A5038077662 @default.
• W2079343346 hasAuthorship W2079343346A5042008157 @default.
• W2079343346 hasAuthorship W2079343346A5048081746 @default.
• W2079343346 hasAuthorship W2079343346A5075889094 @default.
• W2079343346 hasAuthorship W2079343346A5085581217 @default.
• W2079343346 hasAuthorship W2079343346A5086783805 @default.
• W2079343346 hasConcept C117262875 @default.
• W2079343346 hasConcept C121608353 @default.
• W2079343346 hasConcept C126322002 @default.
• W2079343346 hasConcept C143998085 @default.
• W2079343346 hasConcept C150903083 @default.
• W2079343346 hasConcept C206684579 @default.
• W2079343346 hasConcept C207001950 @default.
• W2079343346 hasConcept C2776235491 @default.
• W2079343346 hasConcept C2779306644 @default.
• W2079343346 hasConcept C2780192828 @default.
• W2079343346 hasConcept C2780323712 @default.
• W2079343346 hasConcept C502942594 @default.
• W2079343346 hasConcept C509974204 @default.
• W2079343346 hasConcept C58962609 @default.
• W2079343346 hasConcept C71924100 @default.
• W2079343346 hasConcept C86803240 @default.
• W2079343346 hasConcept C96232424 @default.
• W2079343346 hasConceptScore W2079343346C117262875 @default.
• W2079343346 hasConceptScore W2079343346C121608353 @default.
• W2079343346 hasConceptScore W2079343346C126322002 @default.
• W2079343346 hasConceptScore W2079343346C143998085 @default.
• W2079343346 hasConceptScore W2079343346C150903083 @default.

• next