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• W2079343657 abstract "Pulsed-field gradient nuclear magnetic resonance (PFG-NMR) is a well-established method for the determination of translational diffusion coefficients. Recently, this method has found applicability in the combinatorial arena with the introduction of affinity NMR for characterizing protein/ligand interactions. Although affinity NMR has been reported to be an effective method for the identification of active compounds in a complex mixture, there are limitations of this method. We have developed a simple mathematical model to predict optimum concentration ratios of the ligand and protein in order to observe maximum changes in the ligand diffusion coefficient upon protein binding. The ligand/protein systems of L-tryptophan and ibuprofen binding to human serum albumin were chosen to demonstrate the usefulness of this model. However, even when the conditions of the mathematical model are satisfied, the spectral background arising from the protein in proton-detected experiments can be problematic. To this end, we have employed spectral subtraction of the protein spectrum to yield ligand diffusion coefficients that are in agreement with those predicted by simulation." @default.
• W2079343657 created "2016-06-24" @default.
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• W2079343657 date "2002-04-01" @default.
• W2079343657 modified "2023-10-17" @default.
• W2079343657 title "Analysis of Protein/Ligand Interactions with NMR Diffusion Measurements: The Importance of Eliminating the Protein Background" @default.
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• W2079343657 doi "https://doi.org/10.1006/jmre.2002.2513" @default.
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