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- W2079343888 abstract "Lipopolysaccharide, a potent activator of the immune system, elicits the production of pro-inflammatory mediators in immunocytes. Toll-like receptor 4 (TLR4) and myeloid differentiation factor (MD) 2 receptor complex is required for recognition and signaling of LPS. Previous study suggested water soluble chitosan decreased secretion of pro-inflammatory cytokines TNF-α and IL-6. However, no studies have provided direct target and molecular mechanism of anti-inflammatory effect of chitosan oligosaccharide on LPS-stimulated cells. In this study, we found that chitosan oligosaccharides significantly inhibited binding of LPS to TLR4/MD-2 receptor complex, thus attenuated activation of mitogen-activated protein kinases (MAPKs) and decreased nuclear translocation of nuclear factor-κB (NF-κB). Finally, chitosan oligosaccharides reduced the production of pro-inflammatory mediator, such as IL-1β and nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. Therefore, chitosan oligosaccharides are potential inhibitive effector of LPS." @default.
- W2079343888 created "2016-06-24" @default.
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- W2079343888 date "2010-09-01" @default.
- W2079343888 modified "2023-10-17" @default.
- W2079343888 title "Chitosan oligosaccharides suppressant LPS binding to TLR4/MD-2 receptor complex" @default.
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- W2079343888 doi "https://doi.org/10.1016/j.carbpol.2010.04.079" @default.
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