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• W2079347622 abstract "Reactive oxygen species (ROS) and signaling events are involved in the pathogenesis of endothelial dysfunction and represent a major contribution to vascular regulation. Molecular signaling is highly dependent on ROS. But depending on the amount of ROS production it might have toxic or protective effects. Despite a large number of negative outcomes in large clinical trials (e.g., HOPE, HOPE-TOO), antioxidant molecules and agents are important players to influence the critical balance between production and elimination of reactive oxygen and nitrogen species. However, chronic systemic antioxidant therapy lacks clinical efficacy, probably by interfering with important physiological redox signaling pathways. Therefore, it may be a much more promising attempt to induce intrinsic antioxidant pathways in order to increase the antioxidants not systemically but at the place of oxidative stress and complications. Among others, heme oxygenase (HO) has been shown to be important for attenuating the overall production of ROS in a broad range of disease states through its ability to degrade heme and to produce carbon monoxide and biliverdin/bilirubin. With the present review we would like to highlight the important antioxidant role of the HO system and especially discuss the contribution of the biliverdin, bilirubin, and biliverdin reductase (BVR) to these beneficial effects. The BVR was reported to confer an antioxidant redox amplification cycle by which low, physiological bilirubin concentrations confer potent antioxidant protection via recycling of biliverdin from oxidized bilirubin by the BVR, linking this sink for oxidants to the NADPH pool. To date the existence and role of this antioxidant redox cycle is still under debate and we present and discuss the pros and cons as well as our own findings on this topic." @default.
• W2079347622 created "2016-06-24" @default.
• W2079347622 creator A5039361810 @default.
• W2079347622 creator A5089645796 @default.
• W2079347622 date "2012-01-01" @default.
• W2079347622 modified "2023-10-01" @default.
• W2079347622 title "Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?" @default.
• W2079347622 cites W113714250 @default.
• W2079347622 cites W1485337864 @default.
• W2079347622 cites W1504634754 @default.
• W2079347622 cites W1602232839 @default.
• W2079347622 cites W163993298 @default.
• W2079347622 cites W1678920698 @default.
• W2079347622 cites W1963495254 @default.
• W2079347622 cites W1963989090 @default.
• W2079347622 cites W1966582616 @default.
• W2079347622 cites W1972181963 @default.
• W2079347622 cites W1972252836 @default.
• W2079347622 cites W1972705845 @default.
• W2079347622 cites W1973466019 @default.
• W2079347622 cites W1976596705 @default.
• W2079347622 cites W1979069114 @default.
• W2079347622 cites W1983269004 @default.
• W2079347622 cites W1983329266 @default.
• W2079347622 cites W1983339726 @default.
• W2079347622 cites W1983889201 @default.
• W2079347622 cites W1984248420 @default.
• W2079347622 cites W1984445105 @default.
• W2079347622 cites W1987777210 @default.
• W2079347622 cites W1989750047 @default.
• W2079347622 cites W1992879610 @default.
• W2079347622 cites W1999554896 @default.
• W2079347622 cites W2000393531 @default.
• W2079347622 cites W2002143964 @default.
• W2079347622 cites W2003449292 @default.
• W2079347622 cites W2004522307 @default.
• W2079347622 cites W2004646029 @default.
• W2079347622 cites W2006738521 @default.
• W2079347622 cites W2009521328 @default.
• W2079347622 cites W2011497846 @default.
• W2079347622 cites W2011863986 @default.
• W2079347622 cites W2019148514 @default.
• W2079347622 cites W2021443072 @default.
• W2079347622 cites W2022690437 @default.
• W2079347622 cites W2023376910 @default.
• W2079347622 cites W2025744678 @default.
• W2079347622 cites W2027001200 @default.
• W2079347622 cites W2027872608 @default.
• W2079347622 cites W2029195231 @default.
• W2079347622 cites W2043411266 @default.
• W2079347622 cites W2043768128 @default.
• W2079347622 cites W2046266224 @default.
• W2079347622 cites W2046561530 @default.
• W2079347622 cites W2056762760 @default.
• W2079347622 cites W2065527303 @default.
• W2079347622 cites W2066113949 @default.
• W2079347622 cites W2068461853 @default.
• W2079347622 cites W2073771107 @default.
• W2079347622 cites W2074736115 @default.
• W2079347622 cites W2077703381 @default.
• W2079347622 cites W2078609739 @default.
• W2079347622 cites W2083296775 @default.
• W2079347622 cites W2084304010 @default.
• W2079347622 cites W2100090751 @default.
• W2079347622 cites W2108548586 @default.
• W2079347622 cites W2112107066 @default.
• W2079347622 cites W2118287470 @default.
• W2079347622 cites W2118330121 @default.
• W2079347622 cites W2118563786 @default.
• W2079347622 cites W2118886709 @default.
• W2079347622 cites W2120856924 @default.
• W2079347622 cites W2122410250 @default.
• W2079347622 cites W2124163811 @default.
• W2079347622 cites W2124683065 @default.
• W2079347622 cites W2129139391 @default.
• W2079347622 cites W2131158564 @default.
• W2079347622 cites W2136493270 @default.
• W2079347622 cites W2139020323 @default.
• W2079347622 cites W2144432599 @default.
• W2079347622 cites W2146199086 @default.
• W2079347622 cites W2147136957 @default.
• W2079347622 cites W2148033620 @default.
• W2079347622 cites W2148637873 @default.
• W2079347622 cites W2149094173 @default.
• W2079347622 cites W2158561768 @default.
• W2079347622 cites W2161414034 @default.
• W2079347622 cites W2162583612 @default.
• W2079347622 cites W2165304543 @default.
• W2079347622 cites W2170928666 @default.
• W2079347622 cites W2184247090 @default.
• W2079347622 cites W2320456753 @default.
• W2079347622 cites W2418194756 @default.
• W2079347622 doi "https://doi.org/10.3389/fphar.2012.00030" @default.
• W2079347622 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3306014" @default.
• W2079347622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22438843" @default.
• W2079347622 hasPublicationYear "2012" @default.
• W2079347622 type Work @default.
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